| Tag |
Content |
| dbPAF ID |
dbPAF-0001114 |
| Uniprot Accession |
O18645; O18645_DROME; Q9U4G0;
|
| Genbank Protein ID |
NP_477313.1; NP_726730.1; NP_996327.1;
|
| Genbank Nucleotide ID |
NM_057965.4; NM_166880.2; NM_206604.2;
|
| Protein Name |
AMP-activated protein kinase alpha subunit, isoform A |
| Protein Synonyms/Alias |
|
| Gene Name |
AMPKalpha |
| Gene Synonyms/Alias |
EG:132E8.2;SNF1A;SNF1A-RA;CG3051;Dmel_CG3051; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MPQMRAAAAE AVAAGSANGQ PLVKIGHYLL GATLGTGTFG KVKIGEHQIT RVKVAVKILN 60
RQKIKSLDVV GKIRREIQNL KLFRHPHIIK LYQVISTPSD IFMIMEYVSG GELFDYIVKH 120
GKLQEHQARR FFQQIISGVD YCHRHMIVHR DLKPENLLLD HNMHVKIADF GLSNMMLDGE 180
FLRTSCGSPN YAAPEVISGK LYAGPEVDIW SCGVILYALL CGTLPFDDEH VPTLFRKIKS 240
GIFPIPEYLN KQVVNLVCQM LQVDPLKRAN IEEIKKHEWF QKDLPAYLFP SSIEQDSNVI 300
DTYAVAEVCT KFGVKETEVH NSLLSGDPHD QLAIAYHLII DNKRFADDAA NQINEINNFF 360
VAGSPPPPPP PPVPQSSMDH QAPLATVTVG GGTSASSGTA TPVPPVAGGT PSSTIPIRPH 420
PERIAPMRDR QLAMSVQTSG GGAFPEKTAR GGTPIKRAKW HLGIRSQSKP NDIMLEVYRA 480
MKALSYEWKI INPYHVRVRR QNVKTGKFSK MSLQLYQVDA KSYLLDFKSL TNDEVEQGDD 540
VIMESLTPPP LSVSGVMPLQ PTGHHTMEFF EMCAALIIQL AR
583Fasta Sequence
>O18645|AMPKalpha|Drosophila melanogaster(Fruit fly)
MPQMRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQLAR
|
| Keyword |
KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF16579--AdenylateSensor
PF00069--Pkinase
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0004703--F:G-protein coupled receptor kinase activity
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007411--P:axon guidance
GO:0042595--P:behavioral response to starvation
GO:0042149--P:cellular response to glucose starvation
GO:0009267--P:cellular response to starvation
GO:0048813--P:dendrite morphogenesis
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0035404--P:histone-serine phosphorylation
GO:0035556--P:intracellular signal transduction
GO:0006629--P:lipid metabolic process
GO:0000278--P:mitotic cell cycle
GO:0045792--P:negative regulation of cell size
GO:0032007--P:negative regulation of TOR signaling
GO:0006909--P:phagocytosis
GO:0042331--P:phototaxis
GO:0006468--P:protein phosphorylation
GO:0001558--P:regulation of cell growth
GO:0044058--P:regulation of digestive system process
GO:0030730--P:sequestering of triglyceride
GO:0007165--P:signal transduction
|
