dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001112 |
| Uniprot Accession | O18475; DPOLQ_DROME; Q5BI65; |
| Genbank Protein ID | NP_524333.1; |
| Genbank Nucleotide ID | NM_079609.3; |
| Protein Name | DNA polymerase theta |
| Protein Synonyms/Alias | Mutagen-sensitive protein 308; |
| Gene Name | mus308 |
| Gene Synonyms/Alias | CG6019; |
| Organism | Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID | 7227 |
| Functional Description (View all) |
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:20617203). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MAFSQSFNFG NSTLMALEKG MQADDKENAQ PGNGNIQVQS AGNEVNSEIQ EINSEFFRDE 60 FSYEVNQAHK PAEQSVVNVS QVQQHMAVVS NQDSEDQSRS SALNDQICTQ SSFEGEDAGA 120 DAVLDQPNLD ENSFLCPAQD EEASEQLKED ILHSHSVLAK QEFYQEISQV TQNLSSMSPN 180 QLRVSPNSSR IREAMPERPA MPLDLNTLRS ISAWNLPMSI QAEYKKKGVV DMFDWQVECL 240 SKPRLLFEHC NLVYSAPTSA GKTLVSEILM LKTVLERGKK VLLILPFISV VREKMFYMQD 300 LLTPAGYRVE GFYGGYTPPG GFESLHVAIC TIEKANSIVN KLMEQGKLET IGMVVVDEVH 360 LISDKGRGYI LELLLAKILY MSRRNGLQIQ VITMSATLEN VQLLQSWLDA ELYITNYRPV 420 ALKEMIKVGT VIYDHRLKLV RDVAKQKVLL KGLENDSDDV ALLCIETLLE GCSVIVFCPS 480 KDWCENLAVQ LATAIHVQIK SETVLGQRLR TNLNPRAIAE VKQQLRDIPT GLDGVMSKAI 540 TYACAFHHAG LTTEERDIIE ASFKAGALKV LVATSTLSSG VNLPARRVLI RSPLFGGKQM 600 SSLTYRQMIG RAGRMGKDTL GESILICNEI NARMGRDLVV SELQPITSCL DMDGSTHLKR 660 ALLEVISSGV ANTKEDIDFF VNCTLLSAQK AFHAKEKPPD EESDANYIND ALDFLVEYEF 720 VRLQRNEERE TAVYVATRLG AACLASSMPP TDGLILFAEL QKSRRSFVLE SELHAVYLVT 780 PYSVCYQLQD IDWLLYVHMW EKLSSPMKKV GELVGVRDAF LYKALRGQTK LDYKQMQIHK 840 RFYIALALEE LVNETPINVV VHKYKCHRGM LQSLQQMAST FAGIVTAFCN SLQWSTLALI 900 VSQFKDRLFF GIHRDLIDLM RIPDLSQKRA RALFDAGITS LVELAGADPV ELEKVLYNSI 960 SFDSAKQHDH ENADEAAKRN VVRNFYITGK AGMTVSEAAK LLIGEARQFV QHEIGLGTIK 1020 WTQTQAGVEI ASRAIHDGGE VDLHMSLEEE QPPVKRKLSI EENGTANSQK NPRLETVVDT 1080 QRGYKVDKNI ANQSKMNPNL KEIDAQNKAR RNSTAHMDNL NPISNDPCQN NVNVKTAQPI 1140 ISNLNDIQKQ GSQIEKMKIN PATVVCSPQL ANEEKPSTSQ SARRKLVNEG MAERRRVALM 1200 KIQQRTQKEN QSKDQPIQAS RSNQLSSPVN RTPANRWTQS ENPNNEMNNS QLPRRNPRNQ 1260 SPVPNANRTA SRKVSNAEED LFMADDSFML NTGLAAALTA AESKIASCTE ADVIPSSQPK 1320 EPEVIGALTP HASRLKRSDQ LRSQRIQSPS PTPQREIEID LESKNESNGV SSMEISDMSM 1380 ENPLMKNPLH LNASHIMSCS KVDETASSFS SIDIIDVCGH RNAFQAAIIE INNATRLGFS 1440 VGLQAQAGKQ KPLIGSNLLI NQVAAAENRE AAARERVLFQ VDDTNFISGV SFCLADNVAY 1500 YWNMQIDERA AYQGVPTPLK VQELCNLMAR KDLTLVMHDG KEQLKMLRKA IPQLKRISAK 1560 LEDAKVANWL LQPDKTVNFL NMCQTFAPEC TGLANLCGSG RGYSSYGLDT SSAILPRIRT 1620 AIESCVTLHI LQGQTENLSR IGNGDLLKFF HDIEMPIQLT LCQMELVGFP AQKQRLQQLY 1680 QRMVAVMKKV ETKIYEQHGS RFNLGSSQAV AKVLGLHRKA KGRVTTSRQV LEKLNSPISH 1740 LILGYRKLSG LLAKSIQPLM ECCQADRIHG QSITYTATGR ISMTEPNLQN VAKEFSIQVG 1800 SDVVHISCRS PFMPTDESRC LLSADFCQLE MRILAHMSQD KALLEVMKSS QDLFIAIAAH 1860 WNKIEESEVT QDLRNSTKQV CYGIVYGMGM RSLAESLNCS EQEARMISDQ FHQAYKGIRD 1920 YTTRVVNFAR SKGFVETITG RRRYLENINS DVEHLKNQAE RQAVNSTIQG SAADIAKNAI 1980 LKMEKNIERY REKLALGDNS VDLVMHLHDE LIFEVPTGKA KKIAKVLSLT MENCVKLSVP 2040 LKVKLRIGRS WGEFKEVSV |
| Keyword | KW-0067--ATP-binding |
| Interpro | IPR011545--DEAD/DEAH_box_helicase_dom |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0005634--C:nucleus |