dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001066
Uniprot Accession O17468; HIRA_DROME; O46105; O77144; Q5U0S5; Q8T0C3; Q9W3Q3;
Genbank Protein ID NP_572401.2;
Genbank Nucleotide ID NM_132173.3;
Protein Name Protein HIRA homolog
Protein Synonyms/Alias Protein sesame;dHIRA;
Gene Name Hira
Gene Synonyms/Alias Dhh;ssm;CG12153;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
519PASQRRQSLPFDPGQdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated17372656; 16381945; 23193290; 18327897; 21081558; 19060867;
Sequence
(Fasta)
MRLLKPAWVH HDDKQIFSVD IHKDCTKFAT GGQGSDCGRV VIWNLLPVLS DKAEFDADVP 60
KMLCQMDQHL ACVNCVRWSQ NGQNLASGSD DKLIMIWRKS AGSSGVFGTG GMQKNHESWK 120
CFYTLRGHDG DVLDLAWSPN DVYLASCSID NTVIIWDAQA FPHSVATLKG HTGLVKGVSW 180
DPLGRFLASQ SDDRSIKIWN TMNWSLSHTI TEPFEECGGT THILRLSWSP DGQYLVSAHA 240
MNGGGPTAQI IEREGWKCDK DFVGHRKAVT CVRFHNSILS RQENDGSPSK PLQYCCLAVG 300
SRDRSLSVWM TALQRPMVVI HELFNASILD LTWGPQECLL MACSVDGSIA CLKFTEEELG 360
KAISEEEQNA IIRKMYGKNY VNGLGKSAPV LEHPQRLLLP QGDKPTKFPL SNNNEANQRP 420
ISKQTETRTK DGKRRITPMF IPLHEDGPTS LSMNIVSSSG SSTTALTSCS AAIGTLPAAA 480
PTESAATPLM PLEPLVSKID LGRLDSRLKT QPASQRRQSL PFDPGQSNEL LRTPRLEEHQ 540
SSTCSPSNLN VTATGKSEFV KAALDYRLHV SNGHLKTQHG MLAKVTASDS KEMLWEFYVG 600
SPLVNLNLCE KYAMLCSLDG SMRLISMETG CPVFPAISLT SSAVHCAFSP DNSLVGVLTE 660
CGLLRIWDIA KKVVSLAAGC LELLNKHGTA AQFSVTNQGM PLIGFPSGNS YSYSTSLQSW 720
LVLATKDAIM YHGIRGTLPR DMDQMQQKFP LLSMQASSQN YFSFTGSMEL RHSESWQQCA 780
KIRFIENQIK LCEALQSLDE LQHWHKMLTF QLATHGSEKR MRVFLDDLLS MPEPGISQFV 840
PKLELMQCVL DTLKPHSEWN RLHSEYTELL KECKSERQKD IFATPAPPQQ KTASSAGSSP 900
RSGEATGEEV TEKDGATAVA AAVVAGSRMA VTTGTSTTTT TTASSSLSSS GSSSSTSGSG 960
SSSSSSSTSS LSVPQPAPSL SPEIQTLDSP TVCIDDEILS ASSSLPPLDT SPVEVSPAST 1020
SGGAASTSPA ASVAGSAPVS SSKTDQT 1048
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

Gene Ontology

GO:0042585--C:germinal vesicle
GO:0001673--C:male germ cell nucleus
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0006338--P:chromatin remodeling
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0035042--P:fertilization, exchange of chromosomal proteins
GO:0006355--P:regulation of transcription, DNA-templated
GO:0035041--P:sperm chromatin decondensation
GO:0006351--P:transcription, DNA-templated