| Tag |
Content |
| dbPAF ID |
dbPAF-0001044 |
| Uniprot Accession |
O16844; COS_DROME; A1Z6X4; B5RIP3; Q6AWI9; Q8IH04;
|
| Genbank Protein ID |
NP_001260765.1; NP_477092.1;
|
| Genbank Nucleotide ID |
NM_001273836.1; NM_057744.3;
|
| Protein Name |
Kinesin-like protein costa |
| Protein Synonyms/Alias |
Kinesin-like protein costal2; |
| Gene Name |
cos |
| Gene Synonyms/Alias |
cos2;costal-2;CG1708; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation.Functional Description
Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation. Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form. Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MEIPIQVAVR IFPHRELKDL LRSFGPTEPK KDAQAVDEGA DSKDSEAQVP AAEKDNPSIS 60
ETDPNGNAEQ DSAADSKTIP DANGNDSGQK DYPDSAYCVQ AIPISASALG LPSALPGGDP 120
MDSIAAGLIQ VGPHTVPVTH ALPSSSSQEQ VYHQTVFPLI TLFLEGFDAS VVTYGQRGQG 180
KSYTLYGNVQ DPTLTDSTEG VVQLCVRDIF SHISLHPERT YAINVGFVEI CGGDVCDLLG 240
MGNIHCTNVD AVFHWLQVGL SARQSLPAHT LFTLTLEQQW VSKEGLLQHR LSTASFSDLC 300
GTERCGDQPP GRPLDAGLCM LEQVISTLTD PGLMYGVNGN IPYGQTTLTT LLKDSFGGRA 360
QTLVILCVSP LEEHLPETLG NLQFAFKVQC VRNFVIMNTY SDDNTMIVQP AEPVPESNSS 420
AGPLSQAGPG DNFGLQFAAS QWSKLVTNAE GLFSKLIDSK LITEVEKEQI EEWLFLKQEC 480
EECLSSTEAM RQQKQLVPIL EAEEPEDVNS EAANSESPNS DNENDTDNES HRPDLDDKIE 540
SLMEEFRDKT DALILEKHAE YLSKHPKAVM QSQDREIEAQ PPEENGDDRK VSIGSRRRSV 600
QPGASLSTAE LAMLNRVASQ QPPPPIDPES VVDPLESSSG EGIRQAALAA AAATAPIEQL 660
QKKLRKLVAE IEGKQRQLRE IEETIQVKQN IIAELVKNSD TRSHAKQRFH KKRAKLEAEC 720
DKAKKQLGKA LVQGRDQSEI ERWTTIIGHL ERRLEDLSSM KHIAGESGQK VKKLQQSVGE 780
SRKQADDLQK KLRKECKLRC QMEAELAKLR ESRETGKELV KAQGSPEQQG RQLKAVQARI 840
THLNHILREK SDNLEEQPGP EQQETLRHEI RNLRGTRDLL LEERCHLDRK LKRDKVLTQK 900
EERKLLECDE AIEAIDAAIE FKNEMITGHR SIDTSDRIQR EKGEQMLMAR LNRLSTEEMR 960
TLLYKYFTKV IDLRDSSRKL ELQLVQLERE RDAWEWKERV LSNAVRQARL EGERNAVLLQ 1020
RQHEMKLTLM LRHMAEETSA SSASYGERAL APACVAPPVQ ASSDFDYDHF YKGGGNPSKA 1080
LIKAPKPMPT GSALDKYKDK EQRSGRNIFA KFHVLTRYAS AAAAGSSGST AEESTALIES 1140
TTTATATTTS TTTTGAVGKV KDKALVSFRP EQLKRLMPAP TATKVTRQKN KIIIQDASRR 1200
N
1202Fasta Sequence
>O16844|cos|Drosophila melanogaster(Fruit fly)
MEIPIQVAVRIFPHRELKDLLRSFGPTEPKKDAQAVDEGADSKDSEAQVPAAEKDNPSISETDPNGNAEQDSAADSKTIPDANGNDSGQKDYPDSAYCVQAIPISASALGLPSALPGGDPMDSIAAGLIQVGPHTVPVTHALPSSSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGKSYTLYGNVQDPTLTDSTEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLLGMGNIHCTNVDAVFHWLQVGLSARQSLPAHTLFTLTLEQQWVSKEGLLQHRLSTASFSDLCGTERCGDQPPGRPLDAGLCMLEQVISTLTDPGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFVIMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEGLFSKLIDSKLITEVEKEQIEEWLFLKQECEECLSSTEAMRQQKQLVPILEAEEPEDVNSEAANSESPNSDNENDTDNESHRPDLDDKIESLMEEFRDKTDALILEKHAEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAELAMLNRVASQQPPPPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRKLVAEIEGKQRQLREIEETIQVKQNIIAELVKNSDTRSHAKQRFHKKRAKLEAECDKAKKQLGKALVQGRDQSEIERWTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADDLQKKLRKECKLRCQMEAELAKLRESRETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSDNLEEQPGPEQQETLRHEIRNLRGTRDLLLEERCHLDRKLKRDKVLTQKEERKLLECDEAIEAIDAAIEFKNEMITGHRSIDTSDRIQREKGEQMLMARLNRLSTEEMRTLLYKYFTKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHMAEETSASSASYGERALAPACVAPPVQASSDFDYDHFYKGGGNPSKALIKAPKPMPTGSALDKYKDKEQRSGRNIFAKFHVLTRYASAAAAGSSGSTAEESTALIESTTTATATTTSTTTTGAVGKVKDKALVSFRPEQLKRLMPAPTATKVTRQKNKIIIQDASRRN
|
| Keyword |
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
|
| Interpro |
IPR027640--Kinesin-like_fam
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
|
| PROSITE |
PS50067--KINESIN_MOTOR_2
|
| Pfam |
PF00225--Kinesin
|
| Gene Ontology |
GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0035301--C:Hedgehog signaling complex
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005886--C:plasma membrane
GO:0012506--C:vesicle membrane
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0008017--F:microtubule binding
GO:0003777--F:microtubule motor activity
GO:0003774--F:motor activity
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0005119--F:smoothened binding
GO:0008134--F:transcription factor binding
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0042073--P:intraciliary transport
GO:0007018--P:microtubule-based movement
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0042992--P:negative regulation of transcription factor import into nucleus
GO:0030707--P:ovarian follicle cell development
GO:0007228--P:positive regulation of hh target transcription factor activity
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0042981--P:regulation of apoptotic process
GO:0031647--P:regulation of protein stability
GO:0030162--P:regulation of proteolysis
GO:0007224--P:smoothened signaling pathway
GO:0021591--P:ventricular system development
|
