dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001043
Uniprot Accession O16810; ORC1_DROME; Q9V4N1;
Genbank Protein ID NP_477303.1;
Genbank Nucleotide ID NM_057955.4;
Protein Name Origin recognition complex subunit 1
Protein Synonyms/Alias
Gene Name Orc1
Gene Synonyms/Alias CG10667;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
220RESKRSISARHDDTAPHOSIDA;curated21081558; 22817900
277GRSVVRLSEKKNAPEdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
293NANYLPASPLTEKNAdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;UniProt;curated18327897; 16381945; 23193290; 19060867; 22817900
319ARRNLNLSLDRGADTdbPTM 3.0;PHOSIDA;SysPTM 2.0;curated18327897; 16381945; 23193290; 21081558; 19366988; 22817900
368RRSVRLASMDVDPLSdbPTM 3.0;SysPTM 2.0;UniProt;curated17372656; 16381945; 23193290; 18327897; 19366988; 22817900
403GDIYHTPTKKSKEPLPhosphoPep 2.019060867
419SAAATEQTPSTRRKSdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
422ATEQTPSTRRKSILKdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
426TPSTRRKSILKSATSdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
430RRKSILKSATSRLAEdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
439TSRLAEGTPRRSIHLdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
443AEGTPRRSIHLSNIVdbPTM 3.0;PhosphoPep 2.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19060867; 19366988; 22817900
481QDNDEDYSPKKSVQKdbPTM 3.0;SysPTM 2.0;curated18327897; 16381945; 23193290; 19366988; 22817900
514SKGITTATATPMTPSPHOSIDA;curated21081558; 22817900
533KIRAGELSPSMQQRTdbPTM 3.0;Phospho.ELM 9.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)		MVNKENARSV GQQVKWIGSQ DELPPVKNLE HKNVYFYQKC IYGPLTLSVG DFILVSNADA 60
AEPDTVSGCD VARILHMYEL RELTDREPCR AIVQWYSWPK AIPHNKYDDD EVAIDFSLEV 120
IEEHRPYDND VALGAIYRKC IVLEGTSKTS AEEILKRHAN KLKSTACPMF VSRYRFVKVK 180
RSYRLIPLEI HLEQPEDNAR PTRSSRKSLT AHRESKRSIS ARHDDTAGNK GSSVEKRRRA 240
SMAASSSVEF IDVNSFICEN KVSPIKIVGG RSVVRLSEKK NAPEINANYL PASPLTEKNA 300
KVETPKSRAS AARRNLNLSL DRGADTTADS DCLNYSIVQQ TPDPKTPSND MKIKLRLSER 360
RRSVRLASMD VDPLSLEEAV QEPNAQGRKR LGVANGDIYH TPTKKSKEPL ESAAATEQTP 420
STRRKSILKS ATSRLAEGTP RRSIHLSNIV EQRVFEDDEI ISTPKRGRSK KTVQDNDEDY 480
SPKKSVQKTP TRTRRSSTTT KTATTPSKGI TTATATPMTP SQKMKKIRAG ELSPSMQQRT 540
DLPAKDSSKS ELQLAREQLH VSVVPKSLPC REREFENIYA FLEGKIQDQC GGCMYVSGVP 600
GTGKTATVTG VIRTLQRMAK QNELPAFEYL EINGMRLTEP RQAYVQIYKQ LTGKTVSWEQ 660
AHALLEKRFT TPAPRRVTTV LLVDELDILC NRRQDVVYNL LDWPTKSAAK LVVVTIANTM 720
DLPERLLMGK VTSRLGLTRL TFQPYSHKQL QEIVTARLGG SETFKGEAVQ LVARKVAAVS 780
GDARRALDIC RRATEIADTA AVKCVTMLHV QQALAEMIAS AKVQAIRNCS RMEQIFLQAI 840
AAEVTRTGVE ETTFMGVYQQ VETIAAFMGV TFPPPGRALR LCSKLGAERL IISEHSRNDL 900
FQKILLNVSA DDIHYALRVE EMVN 925
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR001025--BAH_dom
IPR015163--Cdc6_C_dom
IPR027417--P-loop_NTPase
PROSITE

PS51038--BAH
Pfam

PF00004--AAA
PF01426--BAH
PF09079--Cdc6_C
Gene Ontology

GO:0005664--C:nuclear origin of replication recognition complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0008283--P:cell proliferation
GO:0006277--P:DNA amplification
GO:0006270--P:DNA replication initiation
GO:0022008--P:neurogenesis