dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001007
Uniprot Accession O15943; CADN_DROME; Q9VJB7;
Genbank Protein ID NP_724068.1; NP_724069.1; NP_724070.1; NP_724071.1; NP_724072.1; NP_724073.1; NP_724074.1; NP_724075.1;
Genbank Nucleotide ID NM_165224.2; NM_165225.2; NM_165226.2; NM_165227.3; NM_165228.2; NM_165229.2; NM_165230.2; NM_165231.3;
Protein Name Neural-cadherin
Protein Synonyms/Alias Cadherin-N;dN-cadherin;
Gene Name CadN
Gene Synonyms/Alias CG7100;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
1692IFEIEPDTGVIKTAVcurated22817900
Sequence
(Fasta)		MAARRCLNQL RQRYITNRFN ICTCAIFLIS LPFILAIEET TFAGLSAENA ARMLAGSPGD 60
VEKSSLSHHS EMSLVLPHDT YPGFSIKKFK THPVKINGSS HSGAAAYHML DTDYSKYFTV 120
LEDGVVMTTA DISPLVNRPV QLVVVEQTPN ATNTHNLQLF VMHRNDMLRF SGSLLDASGE 180
VRENQPAGTR VRGVPLMQAF SGSILDEELA TPKKVRYTII DGNVDDAFAL QERKANKNIQ 240
ISAKSLVING DDESGVWLVT NRPLDREERA HYDLSVEASD VDGLDRTVSK IQITVLDEND 300
NRPIFKSLDY KFAIAGQKSA SMESNSSVTY QRFAIMGKVE ATDADGDKIA YRLKSPSNVV 360
IIVPQTGEIM LAGEPTSNEL LIEVIAHDLR YPSLVSAKPA KVLLEFLAAE PVSFIMQHLE 420
HDDINNHSHH REKRRVTRAV RPTKRIEFTE ADGDTEGKSV FQLEKETDKE TFKIRDDNPW 480
VTVETNGAVR VKKKWDYEEL GPEKTIDFWV IITNMGHNAG IKYTDNQRVI ILVKDVNDEP 540
PYFINRPLPM QAVVQLNAPP NTPVFTLQAR DPDTDHNIHY FIVRDRTGGR FEVDERSGVV 600
RTRGTDLFQL DMEYVLYVKA EDQNGKVDDR RFQSTPEERL SIVGGKRAPQ FYMPSYEAEI 660
PENQKKDSDI ISIKAKSFAD REIRYTLKAQ GQGAGTFNIG PTSGIVKLAK ELDFEDLRQP 720
HVYSLIVTAT EDSGGFSTSV DLTIRVTDVN DNAPKFELPD YQAHNVDEDI PLGTSILRVK 780
AMDSDSGSNA EIEYLVSDDH FAVDSNGIIV NNKQLDADNN NAYYEFIVTA KDKGEPPKSG 840
VATVRVYTKN KNDEEPKFSQ QVYTPNVDEN AGPNTLVTTV VASDKDGDNV RFGFVGGGTS 900
SGQFVIEDIT GVIRLHNKAI SLDKDKYELN VTAMDDGSCC VNGDQTIHTS TAVVVVFITD 960
VNDNKPVFKD CSTYYPKVEE GAPNGSPVIK VVATDEDKGV NGQVKYSIVQ QPNQKGTKFT 1020
VDEETGEVST NKVFDREGDD GKFVSVTVKA TDQGDPSLEG VCSFTVEITD VNDNPPLFDR 1080
QKYVENVKQD ASIGTNILRV SASDEDADNN GAIVYSLTAP FNPNDLEYFE IQAESGWIVL 1140
KKPLDRETYK LEAMAQDKGY PPLSRTVEVQ IDVVDRANNP PVWDHTVYGP IYVKENMPVG 1200
GKVVSIKASS GIEGNPTVFY RLMPGSTAQT NKFHTFYLQQ RPDNGDTWAD IKVNHPLDYE 1260
SIKEYNLTIR VENNGAQQLA SEATVYIMLE DVNDEIPLFT EREQETVLEG EPIGTKVTQV 1320
NAIDKDGTFP NNQVYYYIVD SPRNEGKEFF EINLQSGEIF TKTVFDREKK GAYALEVEAR 1380
DGAPSARPNS NGPNSVTKFI RIGIADKNDN PPYFDKSLYE AEVDENEDIQ HTVLTVTAKD 1440
HDESSRIRYE ITSGNIGGAF AVKNMTGAIY VAGALDYETR RRYELRLAAS DNLKENYTTV 1500
IIHVKDVNDN PPVFERPTYR TQITEEDDRN LPKRVLQVTA TDGDKDRPQN IVYFLTGQGI 1560
DPDNPANSKF DINRTTGEIF VLKPLDRDQP NGRPQWRFTV FAQDEGGEGL VGYADVQVNL 1620
KDINDNAPIF PQGVYFGNVT ENGTAGMVVM TMTAVDYDDP NEGSNARLVY SIEKNVIEEE 1680
TGSPIFEIEP DTGVIKTAVC CLDRERTPDY SIQVVAMDGG GLKGTGTASI RVKDINDMPP 1740
QFTKDEWFTE VDETDGTALP EMPILTVTVH DEDETNKFQY KVIDNSGYGA DKFTMVRNND 1800
GTGSLKIVQP LDYEDQLQSN GFRFRIQVND KGEDNDNDKY HVAYSWVVVK LRDINDNKPH 1860
FERANVEVSV FEDTKVGTEL EKFKATDPDQ GGKSKVSYSI DRSSDRQRQF AINQNGSVTI 1920
QRSLDREVVP RHQVKILAID DGSPPKTATA TLTVIVQDIN DNAPKFLKDY RPVLPEHVPP 1980
RKVVEILATD DDDRSKSNGP PFQFRLDPSA DDIIRASFKV EQDQKGANGD GMAVISSLRS 2040
FDREQQKEYM IPIVIKDHGS PAMTGTSTLT VIIGDVNDNK MQPGSKDIFV YNYQGQSPDT 2100
PIGRVYVYDL DDWDLPDKKF YWEAMEHPRF KLDEDSGMVT MRAGTREGRY HLRFKVYDRK 2160
HTQTDIPANV TVTVREIPHE AVVNSGSVRL SGISDEDFIR VWNYRTQSMS RSKMDRFRDK 2220
LADLLNTERE NVDIFSVQLK RKHPPLTDVR FSAHGSPYYK PVRLNGIVLM HREEIEKDVG 2280
INITMVGIDE CLYENQMCEG SCTNSLEISP LPYMVNANKT ALVGVRVDTI ADCTCGARNF 2340
TKPESCRTTP CHNGGRCVDT RFGPHCSCPV GYTGPRCQQT TRSFRGNGWA WYPPLEMCDE 2400
SHLSLEFITR KPDGLIIYNG PIVPPERDET LISDFIALEL ERGYPRLLID FGSGTLELRV 2460
KTKKTLDDGE WHRIDLFWDT ESIRMVVDFC KSAEIAEMED GTPPEFDDMS CQARGQIPPF 2520
NEYLNVNAPL QVGGLYREQF DQSLYFWHYM PTAKGFDGCI RNLVHNSKLY DLAHPGLSRN 2580
SVAGCPQTEE VCAQTETTAR CWEHGNCVGS LSEARCHCRP GWTGPACNIP TIPTTFKAQS 2640
YVKYALSFEP DRFSTQVQLR FRTREEYGEL FRVSDQHNRE YGILEIKDGH LHFRYNLNSL 2700
RTEEKDLWLN AIVVNDGQWH VVKVNRYGSA ATLELDGGEG RRYNETFEFV GHQWLLVDKQ 2760
EGVYAGGKAE YTGVRTFEVY ADYQKSCLDD IRLEGKHLPL PPAMNGTQWG QATMARNLEK 2820
GCPSNKPCSN VICPDPFECV DLWNVYECTC GEGRIMSPDS KGCMDRNECL DMPCMNGATC 2880
INLEPRLRYR CICPDGFWGE NCELVQEGQT LKLSMGALAA ILVCLLIILI LVLVFVVYNR 2940
RREAHIKYPG PDDDVRENII NYDDEGGGED DMTAFDITPL QIPIGGPMPP ELAPMKMPIM 3000
YPVMTLMPGQ EPNVGMFIEE HKKRADGDPN APPFDDLRNY AYEGGGSTAG SLSSLASGTD 3060
DEQQEYDYLG AWGPRFDKLA NMYGPEAPNP HNTELEL 3098
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR002126--Cadherin
IPR015919--Cadherin-like
IPR020894--Cadherin_CS
IPR000233--Cadherin_cytoplasmic-dom
IPR027397--Catenin_binding_dom
IPR013320--ConA-like_dom
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR009030--Growth_fac_rcpt_N_dom
IPR001791--Laminin_G
PROSITE

PS00232--CADHERIN_1
PS50268--CADHERIN_2
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS50025--LAM_G_DOMAIN
Pfam

PF00028--Cadherin
PF01049--Cadherin_C
PF00008--EGF
PF02210--Laminin_G_2
Gene Ontology

GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030425--C:dendrite
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0008013--F:beta-catenin binding
GO:0045296--F:cadherin binding
GO:0005509--F:calcium ion binding
GO:0050839--F:cell adhesion molecule binding
GO:0042803--F:protein homodimerization activity
GO:0004872--F:receptor activity
GO:0048675--P:axon extension
GO:0048846--P:axon extension involved in axon guidance
GO:0007411--P:axon guidance
GO:0007412--P:axon target recognition
GO:0007413--P:axonal fasciculation
GO:0016339--P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0044331--P:cell-cell adhesion mediated by cadherin
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules
GO:0050774--P:negative regulation of dendrite morphogenesis
GO:0016318--P:ommatidial rotation
GO:0045467--P:R7 cell development
GO:0045463--P:R8 cell development
GO:0048841--P:regulation of axon extension involved in axon guidance
GO:0048814--P:regulation of dendrite morphogenesis
GO:0031290--P:retinal ganglion cell axon guidance