| Tag |
Content |
| dbPAF ID |
dbPAF-0001006 |
| Uniprot Accession |
O15554; KCNN4_HUMAN; Q53XR4;
|
| Genbank Protein ID |
NP_002241.1;
|
| Genbank Nucleotide ID |
NM_002250.2;
|
| Protein Name |
Intermediate conductance calcium-activated potassium channel protein 4 |
| Protein Synonyms/Alias |
|
| Gene Name |
KCNN4 |
| Gene Synonyms/Alias |
IK1;IKCA1;KCA4;SK4; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).Functional Description
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL 60
VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELVVCGLHPA 120
PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA LLSLAMLLRL YLVPRAVLLR SGVLLNASYR 180
SIGALNQVRF RHWFVAKLYM NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT 240
LWLIPITFLT IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN 300
FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA FRQVRLKHRK 360
LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA GKLDALTELL STALGPRQLP 420
EPSQQSK
428Fasta Sequence
>O15554|KCNN4|Homo sapiens(Human)
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
|
| Keyword |
KW-0112--Calmodulin-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0360--Hereditary hemolytic anemia
KW-0391--Immunity
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR004178--CaM-bd_dom
IPR015449--K_chnl_Ca-activ_SK
IPR013099--K_chnl_dom
|
| PROSITE |
|
| Pfam |
PF02888--CaMBD
PF07885--Ion_trans_2
PF03530--SK_channel
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0045121--C:membrane raft
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0008076--C:voltage-gated potassium channel complex
GO:0015269--F:calcium-activated potassium channel activity
GO:0005516--F:calmodulin binding
GO:0022894--F:Intermediate conductance calcium-activated potassium channel activity
GO:0019903--F:protein phosphatase binding
GO:0006816--P:calcium ion transport
GO:0006884--P:cell volume homeostasis
GO:0006952--P:defense response
GO:0002376--P:immune system process
GO:0045332--P:phospholipid translocation
GO:0050714--P:positive regulation of protein secretion
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:0071435--P:potassium ion export
GO:0071805--P:potassium ion transmembrane transport
GO:0006813--P:potassium ion transport
GO:0046541--P:saliva secretion
GO:0030322--P:stabilization of membrane potential
GO:0007268--P:synaptic transmission
|
