dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001003
Uniprot Accession O15551; CLD3_HUMAN;
Genbank Protein ID NP_001297.1;
Genbank Nucleotide ID NM_001306.3;
Protein Name Claudin-3
Protein Synonyms/Alias Clostridium perfringens enterotoxin receptor 2;CPE-R 2;CPE-receptor 2;Rat ventral prostate.1 protein homolog;hRVP1;
Gene Name CLDN3
Gene Synonyms/Alias C7orf1;CPETR2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
191CPPREKKYTATKVVYPhosphoSitePlus22135298
192PPREKKYTATKVVYSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated15905176; 16381945; 23193290; 18988627; 22135298; 22817900
194REKKYTATKVVYSAPPhosphoSitePlus22135298
198YTATKVVYSAPRSTGdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 20736484; 21253578; 16381945; 23193290; 19060867;
199TATKVVYSAPRSTGPPhosphoSitePlus;curated22135298; 22817900; 25849741; 24972180
203VVYSAPRSTGPGASLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20166139; 16381945; 23193290; 18988627; 22135298; 25627689
204VYSAPRSTGPGASLGPhosphoSitePlus;curated22135298; 25627689
209RSTGPGASLGTGYDRPhosphoSitePlus;UniProt;curated22135298; 24275569; 23898821; 22798277; 25849741
212GPGASLGTGYDRKDYPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25849741
214GASLGTGYDRKDYV-dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 18180459; 20736484; 18988627;
219TGYDRKDYV------dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus18083107; 16381945; 23193290; 18180459; 20736484; 18988627;
Sequence
(Fasta)		MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ 60
MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 120
GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 180
CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV 221
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0856--Williams-Beuren syndrome
Interpro

IPR006187--Claudin
IPR003549--Claudin3
IPR017974--Claudin_CS
IPR004031--PMP22/EMP/MP20/Claudin
PROSITE

PS01346--CLAUDIN
Pfam

PF00822--PMP22_Claudin
Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0016328--C:lateral plasma membrane
GO:0005198--F:structural molecule activity
GO:0004888--F:transmembrane signaling receptor activity
GO:0070830--P:bicellular tight junction assembly
GO:0016338--P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0003382--P:epithelial cell morphogenesis
GO:0051291--P:protein heterooligomerization
GO:0051260--P:protein homooligomerization
GO:0001666--P:response to hypoxia
GO:0007165--P:signal transduction