dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001002
Uniprot Accession O15550; KDM6A_HUMAN; Q52LL9; Q5JVQ7;
Genbank Protein ID NP_066963.2;
Genbank Nucleotide ID NM_021140.3;
Protein Name Lysine-specific demethylase 6A
Protein Synonyms/Alias Histone demethylase UTX;Ubiquitously-transcribed TPR protein on the X chromosome;Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein;
Gene Name KDM6A
Gene Synonyms/Alias UTX;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
387RSKSCSNTSALAARIPhosphoSitePlus22135298
388SKSCSNTSALAARIKPhosphoSitePlus22135298
535TADSSLPTNSVSGQQPhosphoSitePlus22135298
539SLPTNSVSGQQPQLAPhosphoSitePlus22135298
552LALTRVPSVSQPGVRPhosphoSitePlus22135298
769PSHGDSKSPGLLSSDdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22115753; 18452278; 18988627;
811HPAVHTKTDNSVASSPhosphoSitePlus22135298
817KTDNSVASSPSSAIScurated25627689
818TDNSVASSPSSAISTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated15302935; 16381945; 23193290; 15345747; 19413330; 18988627;
820NSVASSPSSAISTATcurated25627689; 25262027
821SVASSPSSAISTATPcurated25627689
824SSPSSAISTATPSPKcurated23090842
827SSAISTATPSPKSTEdbPTM 3.0;PhosphoSitePlus;curated19413330; 16381945; 23193290; 22135298; 23911959; 23090842;
829AISTATPSPKSTEQTdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22115753; 15345747; 19413330;
911GKNGLSNSSILLDKCPHOSIDA21081558
912KNGLSNSSILLDKCPPHOSIDA21081558
925CPPPRPPSSPYPPLPcurated24260401
926PPPRPPSSPYPPLPKPhosphoSitePlus;curated22135298; 24260401
928PRPPSSPYPPLPKDKPhosphoSitePlus;curated22135298; 24260401
1061RSHHKDHSDSESTSSPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25849741
Sequence
(Fasta)		MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG GLDSRLFGFV 60
RFHEDGARTK ALLGKAVRCY ESLILKAEGK VESDFFCQLG HFNLLLEDYP KALSAYQRYY 120
SLQSDYWKNA AFLYGLGLVY FHYNAFQWAI KAFQEVLYVD PSFCRAKEIH LRLGLMFKVN 180
TDYESSLKHF QLALVDCNPC TLSNAEIQFH IAHLYETQRK YHSAKEAYEQ LLQTENLSAQ 240
VKATVLQQLG WMHHTVDLLG DKATKESYAI QYLQKSLEAD PNSGQSWYFL GRCYSSIGKV 300
QDAFISYRQS IDKSEASADT WCSIGVLYQQ QNQPMDALQA YICAVQLDHG HAAAWMDLGT 360
LYESCNQPQD AIKCYLNATR SKSCSNTSAL AARIKYLQAQ LCNLPQGSLQ NKTKLLPSIE 420
EAWSLPIPAE LTSRQGAMNT AQQNTSDNWS GGHAVSHPPV QQQAHSWCLT PQKLQHLEQL 480
RANRNNLNPA QKLMLEQLES QFVLMQQHQM RPTGVAQVRS TGIPNGPTAD SSLPTNSVSG 540
QQPQLALTRV PSVSQPGVRP ACPGQPLANG PFSAGHVPCS TSRTLGSTDT ILIGNNHITG 600
SGSNGNVPYL QRNALTLPHN RTNLTSSAEE PWKNQLSNST QGLHKGQSSH SAGPNGERPL 660
SSTGPSQHLQ AAGSGIQNQN GHPTLPSNSV TQGAALNHLS SHTATSGGQQ GITLTKESKP 720
SGNILTVPET SRHTGETPNS TASVEGLPNH VHQMTADAVC SPSHGDSKSP GLLSSDNPQL 780
SALLMGKANN NVGTGTCDKV NNIHPAVHTK TDNSVASSPS SAISTATPSP KSTEQTTTNS 840
VTSLNSPHSG LHTINGEGME ESQSPMKTDL LLVNHKPSPQ IIPSMSVSIY PSSAEVLKAC 900
RNLGKNGLSN SSILLDKCPP PRPPSSPYPP LPKDKLNPPT PSIYLENKRD AFFPPLHQFC 960
TNPNNPVTVI RGLAGALKLD LGLFSTKTLV EANNEHMVEV RTQLLQPADE NWDPTGTKKI 1020
WHCESNRSHT TIAKYAQYQA SSFQESLREE NEKRSHHKDH SDSESTSSDN SGRRRKGPFK 1080
TIKFGTNIDL SDDKKWKLQL HELTKLPAFV RVVSAGNLLS HVGHTILGMN TVQLYMKVPG 1140
SRTPGHQENN NFCSVNINIG PGDCEWFVVP EGYWGVLNDF CEKNNLNFLM GSWWPNLEDL 1200
YEANVPVYRF IQRPGDLVWI NAGTVHWVQA IGWCNNIAWN VGPLTACQYK LAVERYEWNK 1260
LQSVKSIVPM VHLSWNMARN IKVSDPKLFE MIKYCLLRTL KQCQTLREAL IAAGKEIIWH 1320
GRTKEEPAHY CSICEVEVFD LLFVTNESNS RKTYIVHCQD CARKTSGNLE NFVVLEQYKM 1380
EDLMQVYDQF TLAPPLPSAS S 1402
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0862--Zinc
Interpro

IPR003347--JmjC_dom
IPR029517--KDM6A
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS51184--JMJC
PS50005--TPR
PS50293--TPR_REGION
Pfam

PF02373--JmjC
PF00515--TPR_1
PF13414--TPR_11
PF13181--TPR_8
Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0046872--F:metal ion binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0006325--P:chromatin organization
GO:0003007--P:heart morphogenesis
GO:0051568--P:histone H3-K4 methylation
GO:0001701--P:in utero embryonic development
GO:0048333--P:mesodermal cell differentiation
GO:0035264--P:multicellular organism growth
GO:0001843--P:neural tube closure
GO:0048570--P:notochord morphogenesis
GO:0010468--P:regulation of gene expression
GO:0003016--P:respiratory system process
GO:0032525--P:somite rostral/caudal axis specification