dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000997
Uniprot Accession O15539; RGS5_HUMAN; E9PMP5; Q53XA9; Q599J0;
Genbank Protein ID NP_001182232.1; NP_001241677.1; NP_001241678.1; NP_003608.1;
Genbank Nucleotide ID NM_001195303.2; NM_001254748.1; NM_001254749.1; NM_003617.3;
Protein Name Regulator of G-protein signaling 5
Protein Synonyms/Alias
Gene Name RGS5
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
40VGDLVIPYNEKPEKPdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
73DKLLQNNYGLASFKSPhosphoSitePlus22135298
84SFKSFLKSEFSEENLdbPTM 3.0;PhosphoSitePlus17540411; 16381945; 23193290; 22135298
117AEKAKQIYEEFIQTEPhosphoSitePlus;curated22135298; 23911959
166HALMEKDSLPRFVRSdbPTM 3.0;PhosphoSitePlus17540411; 16381945; 23193290; 22135298
Sequence
(Fasta)		MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT QKTSLDEALQ 60
WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY KKIKSPAKMA EKAKQIYEEF 120
IQTEAPKEVN IDHFTKDITM KNLVEPSLSS FDMAQKRIHA LMEKDSLPRF VRSEFYQELI 180
K 182
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor
Interpro

IPR016137--RGS
IPR024066--RGS_subdom1
PROSITE

PS50132--RGS
Pfam

PF00615--RGS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0009968--P:negative regulation of signal transduction
GO:0043547--P:positive regulation of GTPase activity
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway