| Tag |
Content |
| dbPAF ID |
dbPAF-0000993 |
| Uniprot Accession |
O15533; TPSN_HUMAN; A2AB91; A2ABC0; B0V003; B0V0A6; B2ZUA4; E9PGM2; O15210; O15272; Q5STJ8; Q5STK6; Q5STQ5; Q5STQ6; Q66K65; Q96KK7; Q9HAN8; Q9UEE0; Q9UEE4; Q9UIZ6; Q9Y6K2;
|
| Genbank Protein ID |
NP_003181.3; NP_757345.2; NP_757346.2;
|
| Genbank Nucleotide ID |
NM_003190.4; NM_172208.2; NM_172209.2;
|
| Protein Name |
Tapasin |
| Protein Synonyms/Alias |
|
| Gene Name |
TAPBP |
| Gene Synonyms/Alias |
NGS17;TAPA; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).Functional Description
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MKSLSLLLAV ALGLATAVSA GPAVIECWFV EDASGKGLAK RPGALLLRQG PGEPPPRPDL 60
DPELYLSVHD PAGALQAAFR RYPRGAPAPH CEMSRFVPLP ASAKWASGLT PAQNCPRALD 120
GAWLMVSISS PVLSLSSLLR PQPEPQQEPV LITMATVVLT VLTHTPAPRV RLGQDALLDL 180
SFAYMPPTSE AASSLAPGPP PFGLEWRRQH LGKGHLLLAA TPGLNGQMPA AQEGAVAFAA 240
WDDDEPWGPW TGNGTFWLPR VQPFQEGTYL ATIHLPYLQG QVTLELAVYK PPKVSLMPAT 300
LARAAPGEAP PELLCLVSHF YPSGGLEVEW ELRGGPGGRS QKAEGQRWLS ALRHHSDGSV 360
SLSGHLQPPP VTTEQHGARY ACRIHHPSLP ASGRSAEVTL EVAGLSGPSL EDSVGLFLSA 420
FLLLGLFKAL GWAAVYLSTC KDSKKKAE
449Fasta Sequence
>O15533|TAPBP|Homo sapiens(Human)
MKSLSLLLAVALGLATAVSAGPAVIECWFVEDASGKGLAKRPGALLLRQGPGEPPPRPDLDPELYLSVHDPAGALQAAFRRYPRGAPAPHCEMSRFVPLPASAKWASGLTPAQNCPRALDGAWLMVSISSPVLSLSSLLRPQPEPQQEPVLITMATVVLTVLTHTPAPRVRLGQDALLDLSFAYMPPTSEAASSLAPGPPPFGLEWRRQHLGKGHLLLAATPGLNGQMPAAQEGAVAFAAWDDDEPWGPWTGNGTFWLPRVQPFQEGTYLATIHLPYLQGQVTLELAVYKPPKVSLMPATLARAAPGEAPPELLCLVSHFYPSGGLEVEWELRGGPGGRSQKAEGQRWLSALRHHSDGSVSLSGHLQPPPVTTEQHGARYACRIHHPSLPASGRSAEVTLEVAGLSGPSLEDSVGLFLSAFLLLGLFKALGWAAVYLSTCKDSKKKAE
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003597--Ig_C1-set
IPR008056--Tapasin
|
| PROSITE |
PS50835--IG_LIKE
|
| Pfam |
PF07654--C1-set
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0071556--C:integral component of lumenal side of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0042824--C:MHC class I peptide loading complex
GO:0042288--F:MHC class I protein binding
GO:0042605--F:peptide antigen binding
GO:0015433--F:peptide antigen-transporting ATPase activity
GO:0046978--F:TAP1 binding
GO:0046979--F:TAP2 binding
GO:0051082--F:unfolded protein binding
GO:0042886--P:amide transport
GO:0019885--P:antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0006955--P:immune response
GO:0050823--P:peptide antigen stabilization
GO:0015833--P:peptide transport
GO:0006461--P:protein complex assembly
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
|
