dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000991
Uniprot Accession O15527; OGG1_HUMAN; A8K1E3; O00390; O00670; O00705; O14876; O95488; P78554; Q9BW42; Q9UIK0; Q9UIK1; Q9UIK2; Q9UL34; Q9Y2C0; Q9Y2C1; Q9Y6C3; Q9Y6C4;
Genbank Protein ID NP_002533.1; NP_058212.1; NP_058213.1; NP_058214.1; NP_058434.1; NP_058436.1; NP_058437.1; NP_058438.1;
Genbank Nucleotide ID NM_002542.5; NM_016819.3; NM_016820.3; NM_016821.2; NM_016826.2; NM_016827.2; NM_016828.2; NM_016829.2;
Protein Name N-glycosylase/DNA lyase
Protein Synonyms/Alias
Gene Name OGG1
Gene Synonyms/Alias MMH;MUTM;OGH1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
115QLYHHWGSVDSHFQEPhosphoSitePlus22135298
183VTYHGFPSLQALAGPPhosphoSitePlus22135298
231WLQQLRESSYEEAHKdbPTM 3.0;PhosphoSitePlus19674107; 16381945; 23193290; 22135298
232LQQLRESSYEEAHKAdbPTM 3.0;PhosphoSitePlus19674107; 16381945; 23193290; 22135298
280HIAQRDYSWHPTTSQdbPTM 3.0;PhosphoSitePlus19674107; 16381945; 23193290; 22135298
326FSADLRQSRHAQEPPdbPTM 3.0;PhosphoSitePlus19674107; 16381945; 23193290; 22135298
Sequence
(Fasta)
MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 60
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 120
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 180
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 240
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 300
NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG 346
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0326--Glycosidase
KW-0378--Hydrolase
KW-0456--Lyase
KW-0496--Mitochondrion
KW-0511--Multifunctional enzyme
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR011257--DNA_glycosylase
IPR003265--HhH-GPD_domain
IPR023170--HTH_base_excis_C
IPR004577--Ogg1
IPR012904--OGG_N

PROSITE
Pfam

PF00730--HhH-GPD
PF07934--OGG_N

Gene Ontology

GO:0005739--C:mitochondrion
GO:0016363--C:nuclear matrix
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0034039--F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0003684--F:damaged DNA binding
GO:0004519--F:endonuclease activity
GO:0032357--F:oxidized purine DNA binding
GO:0008534--F:oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0006284--P:base-excision repair
GO:0006285--P:base-excision repair, AP site formation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0045007--P:depurination
GO:0045008--P:depyrimidination
GO:0006281--P:DNA repair
GO:1901291--P:negative regulation of double-strand break repair via single-strand annealing
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0033158--P:regulation of protein import into nucleus, translocation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006979--P:response to oxidative stress
GO:0009314--P:response to radiation