dbPAF Protein Information
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dbPAF ID | dbPAF-0000991 | ||||||||||||||||||||||||||||
Uniprot Accession | O15527; OGG1_HUMAN; A8K1E3; O00390; O00670; O00705; O14876; O95488; P78554; Q9BW42; Q9UIK0; Q9UIK1; Q9UIK2; Q9UL34; Q9Y2C0; Q9Y2C1; Q9Y6C3; Q9Y6C4; | ||||||||||||||||||||||||||||
Genbank Protein ID | NP_002533.1; NP_058212.1; NP_058213.1; NP_058214.1; NP_058434.1; NP_058436.1; NP_058437.1; NP_058438.1; | ||||||||||||||||||||||||||||
Genbank Nucleotide ID | NM_002542.5; NM_016819.3; NM_016820.3; NM_016821.2; NM_016826.2; NM_016827.2; NM_016828.2; NM_016829.2; | ||||||||||||||||||||||||||||
Protein Name | N-glycosylase/DNA lyase | ||||||||||||||||||||||||||||
Protein Synonyms/Alias | |||||||||||||||||||||||||||||
Gene Name | OGG1 | ||||||||||||||||||||||||||||
Gene Synonyms/Alias | MMH;MUTM;OGH1; | ||||||||||||||||||||||||||||
Organism | Homo sapiens(Human) | ||||||||||||||||||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||||||||||||||||||
Functional Description (View all) |
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | ||||||||||||||||||||||||||||
Phosphorylation Sites |
dbPAF PTMs: 6
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Sequence (Fasta) | MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA 60 DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 120 QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 180 FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 240 CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 300 NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG 346 |
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Keyword | KW-0002--3D-structure |
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Interpro | IPR011257--DNA_glycosylase |
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PROSITE | |||||||||||||||||||||||||||||
Pfam | |||||||||||||||||||||||||||||
Gene Ontology | GO:0005739--C:mitochondrion |