| Tag |
Content |
| dbPAF ID |
dbPAF-0000990 |
| Uniprot Accession |
O15525; MAFG_HUMAN;
|
| Genbank Protein ID |
NP_002350.1; NP_116100.2; XP_011521877.1; XP_011521878.1; XP_011521879.1; XP_011521880.1; XP_011521881.1;
|
| Genbank Nucleotide ID |
NM_002359.3; NM_032711.3; XM_011523575.1; XM_011523576.1; XM_011523577.1; XM_011523578.1; XM_011523579.1;
|
| Protein Name |
Transcription factor MafG |
| Protein Synonyms/Alias |
V-maf musculoaponeurotic fibrosarcoma oncogene homolog G;hMAF; |
| Gene Name |
MAFG |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).Functional Description
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MTTPNKGNKA LKVKREPGEN GTSLTDEELV TMSVRELNQH LRGLSKEEIV QLKQRRRTLK 60
NRGYAASCRV KRVTQKEELE KQKAELQQEV EKLASENASM KLELDALRSK YEALQTFART 120
VARSPVAPAR GPLAAGLGPL VPGKVAATSV ITIVKSKTDA RS
163Fasta Sequence
>O15525|MAFG|Homo sapiens(Human)
MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKLELDALRSKYEALQTFARTVARSPVAPARGPLAAGLGPLVPGKVAATSVITIVKSKTDARS
|
| Keyword |
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
|
| Interpro |
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR028551--MafG
IPR008917--TF_DNA-bd
IPR024874--Transciption_factor_Maf
|
| PROSITE |
PS50217--BZIP
|
| Pfam |
PF03131--bZIP_Maf
|
| Gene Ontology |
GO:0005654--C:nucleoplasm
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0030534--P:adult behavior
GO:0007596--P:blood coagulation
GO:0001701--P:in utero embryonic development
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0030641--P:regulation of cellular pH
GO:0045604--P:regulation of epidermal cell differentiation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
|
