dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000989
Uniprot Accession O15523; DDX3Y_HUMAN; B4DK29; B4DXX7; Q8IYV7;
Genbank Protein ID NP_001116137.1; NP_001289481.1; NP_004651.2;
Genbank Nucleotide ID NM_001122665.2; NM_001302552.1; NM_004660.4;
Protein Name ATP-dependent RNA helicase DDX3Y
Protein Synonyms/Alias DEAD box protein 3, Y-chromosomal;
Gene Name DDX3Y
Gene Synonyms/Alias DBY;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
49HLRNREASKGFHDKDPHOSIDA21081558
69CSKDKDAYSSFGSRDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated15144186; 15592455; 16381945; 23193290; 14729942; 18083107;
70SKDKDAYSSFGSRDSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated15570572; 16381945; 23193290; 18988627; 22135298; 25627689
71KDKDAYSSFGSRDSRPhosphoSitePlus;curated22135298; 25627689
74DAYSSFGSRDSRGKPPhosphoSitePlus;curated22135298; 25627689
89GYFSERGSGSRGRFDcurated24961811
101RFDDRGRSDYDGIGNPhosphoSitePlus22135298
103DDRGRSDYDGIGNREdbPTM 3.0;PhosphoSitePlus;curated21253578; 16381945; 23193290; 22135298; 22817900
258AVKENGRYGRRKQYPPhosphoSitePlus22135298
264RYGRRKQYPISLVLAdbPTM 3.0;PhosphoSitePlus;curated20090780; 16381945; 23193290; 22135298; 25627689
281RELAVQIYEEARKFSdbPTM 3.019605366; 16381945; 23193290
299RVRPCVVYGGADIGQdbPTM 3.020090780; 16381945; 23193290
321GCHLLVATPGRLVDMdbPTM 3.018220336; 16381945; 23193290
341IGLDFCKYLVLDEADdbPTM 3.016097034; 16381945; 23193290
408LAVGRVGSTSENITQcurated25627689
436LLDILGATGSDSLTLPhosphoSitePlus22135298
438DILGATGSDSLTLVFPhosphoSitePlus22135298
440LGATGSDSLTLVFVEPhosphoSitePlus22135298
460DSLEDFLYHEGYACTdbPTM 3.020090780; 21447384; 16381945; 23193290
574SWLENMAYEHHYKGGPhosphoSitePlus22135298
Sequence
(Fasta)		MSHVVVKNDP ELDQQLANLD LNSEKQSGGA STASKGRYIP PHLRNREASK GFHDKDSSGW 60
SCSKDKDAYS SFGSRDSRGK PGYFSERGSG SRGRFDDRGR SDYDGIGNRE RPGFGRFERS 120
GHSRWCDKSV EDDWSKPLPP SERLEQELFS GGNTGINFEK YDDIPVEATG SNCPPHIENF 180
SDIDMGEIIM GNIELTRYTR PTPVQKHAIP IIKGKRDLMA CAQTGSGKTA AFLLPILSQI 240
YTDGPGEALK AVKENGRYGR RKQYPISLVL APTRELAVQI YEEARKFSYR SRVRPCVVYG 300
GADIGQQIRD LERGCHLLVA TPGRLVDMME RGKIGLDFCK YLVLDEADRM LDMGFEPQIR 360
RIVEQDTMPP KGVRHTMMFS ATFPKEIQML ARDFLDEYIF LAVGRVGSTS ENITQKVVWV 420
EDLDKRSFLL DILGATGSDS LTLVFVETKK GADSLEDFLY HEGYACTSIH GDRSQRDREE 480
ALHQFRSGKS PILVATAVAA RGLDISNVRH VINFDLPSDI EEYVHRIGRT GRVGNLGLAT 540
SFFNEKNMNI TKDLLDLLVE AKQEVPSWLE NMAYEHHYKG GSRGRSKSNR FSGGFGARDY 600
RQSSGSSSSG FGASRGSSSR SGGGGYGNSR GFGGGGYGGF YNSDGYGGNY NSQGVDWWGN 660
661
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0832--Ubl conjugation
Interpro

IPR011545--DEAD/DEAH_box_helicase_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000629--RNA-helicase_DEAD-box_CS
IPR014014--RNA_helicase_DEAD_Q_motif
PROSITE

PS00039--DEAD_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51195--Q_MOTIF
Pfam

PF00270--DEAD
PF00271--Helicase_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0003677--F:DNA binding
GO:0003723--F:RNA binding
GO:0007059--P:chromosome segregation
GO:0010468--P:regulation of gene expression
GO:0010501--P:RNA secondary structure unwinding
GO:0006413--P:translational initiation