dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000987
Uniprot Accession O15520; FGF10_HUMAN; C7FDY0; Q6FHR3; Q6FHT6; Q96P59;
Genbank Protein ID NP_004456.1; XP_005248321.1;
Genbank Nucleotide ID NM_004465.1; XM_005248264.2;
Protein Name Fibroblast growth factor 10
Protein Synonyms/Alias
Gene Name FGF10
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
114PYSILEITSVEIGVVdbPTM 3.0;PhosphoSitePlus;curated20036575; 16381945; 23193290; 22135298; 22817900
161ERIEENGYNTYASFNdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
164EENGYNTYASFNWQHdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)
MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP 60
SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV 120
VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL 180
NGKGAPRRGQ KTRRKNTSAH FLPMVVHS 209
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0038--Ectodermal dysplasia
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-0953--Lacrimo-auriculo-dento-digital syndrome
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal

Interpro

IPR008996--Cytokine_IL1-like
IPR028252--FGF10
IPR002209--Fibroblast_GF_fam
IPR028142--IL-1_fam/FGF_fam

PROSITE

PS00247--HBGF_FGF

Pfam

PF00167--FGF

Gene Ontology

GO:0009986--C:cell surface
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0042056--F:chemoattractant activity
GO:0005104--F:fibroblast growth factor receptor binding
GO:0008083--F:growth factor activity
GO:0008201--F:heparin binding
GO:0005111--F:type 2 fibroblast growth factor receptor binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0000187--P:activation of MAPK activity
GO:0000186--P:activation of MAPKK activity
GO:0001525--P:angiogenesis
GO:0007411--P:axon guidance
GO:0001974--P:blood vessel remodeling
GO:0060667--P:branch elongation involved in salivary gland morphogenesis
GO:0048754--P:branching morphogenesis of an epithelial tube
GO:0060436--P:bronchiole morphogenesis
GO:0060449--P:bud elongation involved in lung branching
GO:0060447--P:bud outgrowth involved in lung branching
GO:0007368--P:determination of left/right symmetry
GO:0031076--P:embryonic camera-type eye development
GO:0048557--P:embryonic digestive tract morphogenesis
GO:0030538--P:embryonic genitalia morphogenesis
GO:0009880--P:embryonic pattern specification
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0010631--P:epithelial cell migration
GO:0050673--P:epithelial cell proliferation
GO:0060664--P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070371--P:ERK1 and ERK2 cascade
GO:0000132--P:establishment of mitotic spindle orientation
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0048807--P:female genitalia morphogenesis
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0060595--P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069--P:hair follicle morphogenesis
GO:0070384--P:Harderian gland development
GO:0050930--P:induction of positive chemotaxis
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0043616--P:keratinocyte proliferation
GO:0032808--P:lacrimal gland development
GO:0060174--P:limb bud formation
GO:0060428--P:lung epithelium development
GO:0061115--P:lung proximal/distal axis specification
GO:0060430--P:lung saccule development
GO:0048808--P:male genitalia morphogenesis
GO:0060615--P:mammary gland bud formation
GO:0000165--P:MAPK cascade
GO:0060915--P:mesenchymal cell differentiation involved in lung development
GO:0060496--P:mesenchymal-epithelial cell signaling involved in lung development
GO:0001823--P:mesonephros development
GO:0001656--P:metanephros development
GO:0003338--P:metanephros morphogenesis
GO:0042693--P:muscle cell fate commitment
GO:0071157--P:negative regulation of cell cycle arrest
GO:0045596--P:negative regulation of cell differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001759--P:organ induction
GO:0030916--P:otic vesicle formation
GO:0031016--P:pancreas development
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0021983--P:pituitary gland development
GO:0050918--P:positive chemotaxis
GO:0032781--P:positive regulation of ATPase activity
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0031659--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0045739--P:positive regulation of DNA repair
GO:0045740--P:positive regulation of DNA replication
GO:0010634--P:positive regulation of epithelial cell migration
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0060054--P:positive regulation of epithelial cell proliferation involved in wound healing
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0071338--P:positive regulation of hair follicle cell proliferation
GO:0051549--P:positive regulation of keratinocyte migration
GO:0010838--P:positive regulation of keratinocyte proliferation
GO:0050671--P:positive regulation of lymphocyte proliferation
GO:0043410--P:positive regulation of MAPK cascade
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0046579--P:positive regulation of Ras protein signal transduction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0050677--P:positive regulation of urothelial cell proliferation
GO:0030949--P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0070352--P:positive regulation of white fat cell proliferation
GO:0060513--P:prostatic bud formation
GO:0034394--P:protein localization to cell surface
GO:0060019--P:radial glial cell differentiation
GO:0007265--P:Ras protein signal transduction
GO:0032925--P:regulation of activin receptor signaling pathway
GO:0060665--P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0046877--P:regulation of saliva secretion
GO:0008589--P:regulation of smoothened signaling pathway
GO:0032355--P:response to estradiol
GO:0032496--P:response to lipopolysaccharide
GO:0007431--P:salivary gland development
GO:0061033--P:secretion by lung epithelial cell involved in lung growth
GO:0060879--P:semicircular canal fusion
GO:0007264--P:small GTPase mediated signal transduction
GO:0051145--P:smooth muscle cell differentiation
GO:0035019--P:somatic stem cell population maintenance
GO:0048536--P:spleen development
GO:0060661--P:submandibular salivary gland formation
GO:0070075--P:tear secretion
GO:0048538--P:thymus development
GO:0030878--P:thyroid gland development
GO:0042246--P:tissue regeneration
GO:0060510--P:Type II pneumocyte differentiation
GO:0050674--P:urothelial cell proliferation
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0050872--P:white fat cell differentiation
GO:0042060--P:wound healing