| Tag |
Content |
| dbPAF ID |
dbPAF-0000986 |
| Uniprot Accession |
O15519; CFLAR_HUMAN; B4DJE0; B7Z9F9; O14673; O14674; O14675; O15137; O15138; O15356; O15510; O43618; O43619; O43620; O60458; O60459; Q53TS6; Q54AF1; Q96TE4; Q9UEW1;
|
| Genbank Protein ID |
NP_001120655.1; NP_001120656.1; NP_001189444.1; NP_001189445.1; NP_001189446.1; NP_001189447.1; NP_001189448.1; NP_001294971.1; NP_003870.4; XP_011510402.1;
|
| Genbank Nucleotide ID |
NM_001127183.2; NM_001127184.2; NM_001202515.1; NM_001202516.1; NM_001202517.1; NM_001202518.1; NM_001202519.1; NM_001308042.1; NM_003879.5; XM_011512100.1;
|
| Protein Name |
CASP8 and FADD-like apoptosis regulator |
| Protein Synonyms/Alias |
Caspase homolog;CASH;Caspase-eight-related protein;Casper;Caspase-like apoptosis regulatory protein;CLARP;Cellular FLICE-like inhibitory protein;c-FLIP;FADD-like antiapoptotic molecule 1;FLAME-1;Inhibitor of FLICE;I-FLICE;MACH-related inducer of toxicity;MRIT;Usurpin; |
| Gene Name |
CFLAR |
| Gene Synonyms/Alias |
CASH;CASP8AP1;CLARP;MRIT; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.Functional Description
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 60
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 120
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 180
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 240
EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 300
EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 360
VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 420
SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT 480
481Fasta Sequence
>O15519|CFLAR|Homo sapiens(Human)
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
|
| Interpro |
IPR029030--Caspase-like_dom
IPR011029--DEATH-like_dom
IPR001875--DED_dom
IPR011600--Pept_C14_caspase
IPR001309--Pept_C14_ICE_p20
IPR015917--Pept_C14A_p45_core
|
| PROSITE |
PS50208--CASPASE_P20
PS50168--DED
|
| Pfam |
PF01335--DED
PF00656--Peptidase_C14
|
| Gene Ontology |
GO:0031265--C:CD95 death-inducing signaling complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031264--C:death-inducing signaling complex
GO:0045121--C:membrane raft
GO:0097342--C:ripoptosome
GO:0097199--F:cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0035877--F:death effector domain binding
GO:0008047--F:enzyme activator activity
GO:0002020--F:protease binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0006915--P:apoptotic process
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0070266--P:necroptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901740--P:negative regulation of myoblast fusion
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0012501--P:programmed cell death
GO:0097300--P:programmed necrotic cell death
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0060544--P:regulation of necroptotic process
GO:0010939--P:regulation of necrotic cell death
GO:0014842--P:regulation of satellite cell proliferation
GO:0014732--P:skeletal muscle atrophy
GO:0007519--P:skeletal muscle tissue development
GO:0043403--P:skeletal muscle tissue regeneration
GO:0014866--P:skeletal myofibril assembly
GO:0016032--P:viral process
|
