| Tag |
Content |
| dbPAF ID |
dbPAF-0000984 |
| Uniprot Accession |
O15514; RPB4_HUMAN; Q52LT4;
|
| Genbank Protein ID |
NP_004796.1;
|
| Genbank Nucleotide ID |
NM_004805.3;
|
| Protein Name |
DNA-directed RNA polymerase II subunit RPB4 |
| Protein Synonyms/Alias |
|
| Gene Name |
POLR2D |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).Functional Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAAGGSDPRA GDVEEDASQL IFPKEFETAE TLLNSEVHML LEHRKQQNES AEDEQELSEV 60
FMKTLNYTAR FSRFKNRETI ASVRSLLLQK KLHKFELACL ANLCPETAEE SKALIPSLEG 120
RFEDEELQQI LDDIQTKRSF QY
143Fasta Sequence
>O15514|POLR2D|Homo sapiens(Human)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY
|
| Keyword |
KW-0002--3D-structure
KW-0181--Complete proteome
KW-0240--DNA-directed RNA polymerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
|
| Interpro |
IPR010997--HRDC-like
IPR005574--RNA_pol_II_Rpb4
IPR006590--RNA_pol_II_Rpb4_core
|
| PROSITE |
|
| Pfam |
PF03874--RNA_pol_Rpb4
|
| Gene Ontology |
GO:0000932--C:cytoplasmic mRNA processing body
GO:0005665--C:DNA-directed RNA polymerase II, core complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003899--F:DNA-directed RNA polymerase activity
GO:0000166--F:nucleotide binding
GO:0031369--F:translation initiation factor binding
GO:0006370--P:7-methylguanosine mRNA capping
GO:0006281--P:DNA repair
GO:0010467--P:gene expression
GO:0031047--P:gene silencing by RNA
GO:0031990--P:mRNA export from nucleus in response to heat stress
GO:0000398--P:mRNA splicing, via spliceosome
GO:0000288--P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006289--P:nucleotide-excision repair
GO:0034587--P:piRNA metabolic process
GO:0045948--P:positive regulation of translational initiation
GO:0050434--P:positive regulation of viral transcription
GO:0034402--P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
GO:0008380--P:RNA splicing
GO:0035019--P:somatic stem cell population maintenance
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0016032--P:viral process
|
