dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000982
Uniprot Accession O15504; NUPL2_HUMAN; A4D143; B4DP42; Q49AE7; Q9BS49;
Genbank Protein ID NP_031368.1;
Genbank Nucleotide ID NM_007342.2;
Protein Name Nucleoporin-like protein 2
Protein Synonyms/Alias NLP-1;NUP42 homolog;Nucleoporin hCG1;
Gene Name NUPL2
Gene Synonyms/Alias CG1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
79SRDQEKPYFSSFDSGdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
82QEKPYFSSFDSGASTdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
85PYFSSFDSGASTNRKcurated25627689; 20068231
88SSFDSGASTNRKEGFcurated25627689; 23917254
89SFDSGASTNRKEGFGcurated25627689
104LSENPFASLSPDEQKPhosphoSitePlus;curated22135298; 23898821
106ENPFASLSPDEQKDEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 20068231; 22115753; 18988627;
138GQWMFSVYSPVKKKPPhosphoSitePlus22135298
139QWMFSVYSPVKKKPNPhosphoSitePlus22135298
305AASFSFKSPAASSFGdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
309SFKSPAASSFGSPGFdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689
310FKSPAASSFGSPGFScurated25627689
313PAASSFGSPGFSGLPPhosphoSitePlus;curated22135298; 25627689
317SFGSPGFSGLPASLAdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558; 22817900
347SSVAGFGSPGSHSHTdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 19060867;
Sequence
(Fasta)		MAICQFFLQG RCRFGDRCWN EHPGARGAGG GRQQPQQQPS GNNRRGWNTT SQRYSNVIQP 60
SSFSKSTPWG GSRDQEKPYF SSFDSGASTN RKEGFGLSEN PFASLSPDEQ KDEKKLLEGI 120
VKDMEVWESS GQWMFSVYSP VKKKPNISGF TDISPEELRL EYHNFLTSNN LQSYLNSVQR 180
LINQWRNRVN ELKSLNISTK VALLSDVKDG VNQAAPAFGF GSSQAATFMS PGFPVNNSSS 240
DNAQNFSFKT NSGFAAASSG SPAGFGSSPA FGAAASTSSG ISTSAPAFGF GKPEVTSAAS 300
FSFKSPAASS FGSPGFSGLP ASLATGPVRA PVAPAFGGGS SVAGFGSPGS HSHTAFSKPS 360
SDTFGNSSIS TSLSASSSII ATDNVLFTPR DKLTVEELEQ FQSKKFTLGK IPLKPPPLEL 420
LNV 424
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000571--Znf_CCCH
PROSITE

PS50103--ZF_C3H1
Pfam
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0001750--C:photoreceptor outer segment
GO:0046872--F:metal ion binding
GO:0005049--F:nuclear export signal receptor activity
GO:0044822--F:poly(A) RNA binding
GO:0005975--P:carbohydrate metabolic process
GO:0044267--P:cellular protein metabolic process
GO:0034605--P:cellular response to heat
GO:0019221--P:cytokine-mediated signaling pathway
GO:0010467--P:gene expression
GO:0031047--P:gene silencing by RNA
GO:0015758--P:glucose transport
GO:0008645--P:hexose transport
GO:0000278--P:mitotic cell cycle
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0019048--P:modulation by virus of host morphology or physiology
GO:0019054--P:modulation by virus of host process
GO:0051028--P:mRNA transport
GO:0043687--P:post-translational protein modification
GO:0006611--P:protein export from nucleus
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0044281--P:small molecule metabolic process
GO:0055085--P:transmembrane transport
GO:0008033--P:tRNA processing
GO:0019058--P:viral life cycle
GO:0016032--P:viral process
GO:0019083--P:viral transcription