| Tag |
Content |
| dbPAF ID |
dbPAF-0000979 |
| Uniprot Accession |
O15496; PA2GX_HUMAN; Q14DU3; Q6NT23;
|
| Genbank Protein ID |
NP_003552.1;
|
| Genbank Nucleotide ID |
NM_003561.1;
|
| Protein Name |
Group 10 secretory phospholipase A2 |
| Protein Synonyms/Alias |
Group X secretory phospholipase A2;GX sPLA2;sPLA2-X;Phosphatidylcholine 2-acylhydrolase 10; |
| Gene Name |
PLA2G10 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.Functional Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MGPLPVCLPI MLLLLLPSLL LLLLLPGPGS GEASRILRVH RRGILELAGT VGCVGPRTPI 60
AYMKYGCFCG LGGHGQPRDA IDWCCHGHDC CYTRAEEAGC SPKTERYSWQ CVNQSVLCGP 120
AENKCQELLC KCDQEIANCL AQTEYNLKYL FYPQFLCEPD SPKCD
166Fasta Sequence
>O15496|PLA2G10|Homo sapiens(Human)
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
|
| Keyword |
KW-0002--3D-structure
KW-0106--Calcium
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR001211--PLipase_A2
IPR013090--PLipase_A2_AS
IPR016090--PLipase_A2_dom
|
| PROSITE |
PS00119--PA2_ASP
PS00118--PA2_HIS
|
| Pfam |
PF00068--Phospholip_A2_1
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005509--F:calcium ion binding
GO:0004623--F:phospholipase A2 activity
GO:0004620--F:phospholipase activity
GO:0019369--P:arachidonic acid metabolic process
GO:0007411--P:axon guidance
GO:0042632--P:cholesterol homeostasis
GO:0046474--P:glycerophospholipid biosynthetic process
GO:0016042--P:lipid catabolic process
GO:0051977--P:lysophospholipid transport
GO:0090370--P:negative regulation of cholesterol efflux
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0006654--P:phosphatidic acid biosynthetic process
GO:0036151--P:phosphatidylcholine acyl-chain remodeling
GO:0036152--P:phosphatidylethanolamine acyl-chain remodeling
GO:0036148--P:phosphatidylglycerol acyl-chain remodeling
GO:0036149--P:phosphatidylinositol acyl-chain remodeling
GO:0036150--P:phosphatidylserine acyl-chain remodeling
GO:0006644--P:phospholipid metabolic process
GO:0090238--P:positive regulation of arachidonic acid secretion
GO:0032270--P:positive regulation of cellular protein metabolic process
GO:0010884--P:positive regulation of lipid storage
GO:0010744--P:positive regulation of macrophage derived foam cell differentiation
GO:0032308--P:positive regulation of prostaglandin secretion
GO:0043030--P:regulation of macrophage activation
GO:0044281--P:small molecule metabolic process
|
