dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000978
Uniprot Accession O15492; RGS16_HUMAN; B2R4M4; Q5VYN9; Q99701;
Genbank Protein ID NP_002919.3;
Genbank Nucleotide ID NM_002928.3;
Protein Name Regulator of G-protein signaling 16
Protein Synonyms/Alias
Gene Name RGS16
Gene Synonyms/Alias RGSR;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
71ESFDLLLSSKNGVAAPhosphoSitePlus22135298
72SFDLLLSSKNGVAAFPhosphoSitePlus22135298
167RTLMEKDSYPRFLKScurated26074081
168TLMEKDSYPRFLKSPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated11602604; 16381945; 23193290; 12588871; 18988627; 22135298;
177RFLKSPAYRDLAAQAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated11602604; 16381945; 23193290; 12588871; 18988627; 22135298;
195SATLSSCSLDEPSHTdbPTM 3.0;HPRD 911522288; 16381945; 23193290; 18988627
Sequence
(Fasta)		MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL 60
GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE 120
FICSEAPKEV NIDHETHELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL 180
AAQASAASAT LSSCSLDEPS HT 203
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0734--Signal transduction inhibitor
Interpro

IPR016137--RGS
IPR024066--RGS_subdom1
PROSITE

PS50132--RGS
Pfam

PF00615--RGS
Gene Ontology

GO:0005737--C:cytoplasm
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0005516--F:calmodulin binding
GO:0005096--F:GTPase activator activity
GO:0009968--P:negative regulation of signal transduction
GO:0043547--P:positive regulation of GTPase activity
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0007601--P:visual perception