| Tag |
Content |
| dbPAF ID |
dbPAF-0000976 |
| Uniprot Accession |
O15484; CAN5_HUMAN; O00263;
|
| Genbank Protein ID |
NP_004046.2;
|
| Genbank Nucleotide ID |
NM_004055.4;
|
| Protein Name |
Calpain-5 |
| Protein Synonyms/Alias |
Calpain htra-3;New calpain 3;nCL-3; |
| Gene Name |
CAPN5 |
| Gene Synonyms/Alias |
NCL3; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 14 | PYEDQNYSALRRDCR | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MFSCVKPYED QNYSALRRDC RRRKVLFEDP LFPATDDSLY YKGTPGPAVR WKRPKGICED 60
PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWD PEKPNAYAGI 120
FHFHFWRFGE WVDVVIDDRL PTVNNQLIYC HSNSRNEFWC ALVEKAYAKL AGCYQALDGG 180
NTADALVDFT GGVSEPIDLT EGDFANDETK RNQLFERMLK VHSRGGLISA SIKAVTAADM 240
EARLACGLVK GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WNGPWSDTSE 300
EWQKVSKSER EKMGVTVQDD GEFWMTFEDV CRYFTDIIKC RVINTSHLSI HKTWEEARLH 360
GAWTLHEDPR QNRGGGCINH KDTFFQNPQY IFEVKKPEDE VLICIQQRPK RSTRREGKGE 420
NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR TDQPEGRYVI IPTTFEPGHT 480
GEFLLRVFTD VPSNCRELRL DEPPHTCWSS LCGYPQLVTQ VHVLGAAGLK DSPTGANSYV 540
IIKCEGDKVR SAVQKGTSTP EYNVKGIFYR KKLSQPITVQ VWNHRVLKDE FLGQVHLKAD 600
PDNLQALHTL HLRDRNSRQP SNLPGTVAVH ILSSTSLMAV
641Fasta Sequence
>O15484|CAPN5|Homo sapiens(Human)
MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV
|
| Keyword |
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
|
| Interpro |
IPR000008--C2_dom
IPR022684--Calpain_cysteine_protease
IPR022682--Calpain_domain_III
IPR022683--Calpain_III
IPR000169--Pept_cys_AS
IPR001300--Peptidase_C2_calpain_cat
|
| PROSITE |
PS50203--CALPAIN_CAT
PS00139--THIOL_PROTEASE_CYS
|
| Pfam |
PF00168--C2
PF01067--Calpain_III
PF00648--Peptidase_C2
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0004198--F:calcium-dependent cysteine-type endopeptidase activity
GO:0060014--P:granulosa cell differentiation
GO:0001553--P:luteinization
GO:0001541--P:ovarian follicle development
GO:0006508--P:proteolysis
GO:0007165--P:signal transduction
|
