dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000970
Uniprot Accession O15460; P4HA2_HUMAN; D3DQ85; D3DQ86; Q8WWN0;
Genbank Protein ID NP_001017973.1; NP_001017974.1; NP_001136070.1; NP_001136071.1; NP_004190.1; XP_005272173.1; XP_005272174.1; XP_005272175.1; XP_005272176.1; XP_005272177.1; XP_006714791.1; XP_006714792.1; XP_006714793.1;
Genbank Nucleotide ID NM_001017973.1; NM_001017974.1; NM_001142598.1; NM_001142599.1; NM_004199.2; XM_005272116.3; XM_005272117.3; XM_005272118.3; XM_005272119.3; XM_005272120.3; XM_006714728.2; XM_006714729.2; XM_006714730.2;
Protein Name Prolyl 4-hydroxylase subunit alpha-2
Protein Synonyms/Alias
Gene Name P4HA2
Gene Synonyms/Alias UNQ290/PRO330;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
79SAADAEGYLAHPVNAPhosphoSitePlus22135298
421ELLQVANYGVGGQYEPhosphoSitePlus22135298
441SRNDERDTFKHLGTGPhosphoSitePlus22135298
447DTFKHLGTGNRVATFPhosphoSitePlus22135298
482AIWPKKGTAVFWYNLPhosphoSitePlus22135298
487KGTAVFWYNLLRSGEPhosphoSitePlus22135298
Sequence
(Fasta)		MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS 60
WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR 120
QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG 180
DYYHTVLWME QVLKQLDAGE EATTTKSQVL DYLSYAVFQL GDLHRALELT RRLLSLDPSH 240
ERAGGNLRYF EQLLEEEREK TLTNQTEAEL ATPEGIYERP VDYLPERDVY ESLCRGEGVK 300
LTPRRQKRLF CRYHHGNRAP QLLIAPFKEE DEWDSPHIVR YYDVMSDEEI ERIKEIAKPK 360
LARATVRDPK TGVLTVASYR VSKSSWLEED DDPVVARVNR RMQHITGLTV KTAELLQVAN 420
YGVGGQYEPH FDFSRNDERD TFKHLGTGNR VATFLNYMSD VEAGGATVFP DLGAAIWPKK 480
GTAVFWYNLL RSGEGDYRTR HAACPVLVGC KWVSNKWFHE RGQEFLRPCG STEVD 536
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0408--Iron
KW-0479--Metal-binding
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0732--Signal
KW-0802--TPR repeat
KW-0847--Vitamin C
Interpro

IPR005123--Oxoglu/Fe-dep_dioxygenase
IPR006620--Pro_4_hyd_alph
IPR013547--Pro_4_hyd_alph_N
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS51471--FE2OG_OXY
PS50005--TPR
PS50293--TPR_REGION
Pfam

PF13640--2OG-FeII_Oxy_3
PF08336--P4Ha_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005788--C:endoplasmic reticulum lumen
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005634--C:nucleus
GO:0016222--C:procollagen-proline 4-dioxygenase complex
GO:0009055--F:electron carrier activity
GO:0005506--F:iron ion binding
GO:0031418--F:L-ascorbic acid binding
GO:0016702--F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004656--F:procollagen-proline 4-dioxygenase activity
GO:0018401--P:peptidyl-proline hydroxylation to 4-hydroxy-L-proline