dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000969
Uniprot Accession O15457; MSH4_HUMAN; Q5T4U6; Q8NEB3; Q9UNP8;
Genbank Protein ID NP_002431.2;
Genbank Nucleotide ID NM_002440.3;
Protein Name MutS protein homolog 4
Protein Synonyms/Alias
Gene Name MSH4
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
132GNPQRSGYKSWTPQVPhosphoSitePlus;curated22135298; 22817900
175RGEIGMASIDLKNPQcurated24961811
341TLFGVLNYTKTPGGSPhosphoSitePlus22135298
348YTKTPGGSRRLRSNIPhosphoSitePlus22135298
467IILEKIKTVINDDARPhosphoSitePlus22135298
475VINDDARYMKGCLNMPhosphoSitePlus22135298
492QKCYAVRSNINEFLDPhosphoSitePlus22135298
704QIMAQIGSYVPAEYSPhosphoSitePlus22135298
712YVPAEYSSFRIAKQIPhosphoSitePlus22135298
865VLDAKEITTQITRQIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
878QILQNQRSTPEMERQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
879ILQNQRSTPEMERQRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
889MERQRAVYHLATRLVPhosphoSitePlus22135298
893RAVYHLATRLVQTARPhosphoSitePlus22135298
927YKEDFPRTEQVPEKTcurated24888630
Sequence
(Fasta)		MLRPEISSTS PSAPAVSPSS GETRSPQGPR YNFGLQETPQ SRPSVQVVSA STCPGTSGAA 60
GDRSSSSSSL PCPAPNSRPA QGSYFGNKRA YAENTVASNF TFGASSSSAR DTNYPQTLKT 120
PLSTGNPQRS GYKSWTPQVG YSASSSSAIS AHSPSVIVAV VEGRGLARGE IGMASIDLKN 180
PQIILSQFAD NTTYAKVITK LKILSPLEII MSNTACAVGN STKLFTLITE NFKNVNFTTI 240
QRKYFNETKG LEYIEQLCIA EFSTVLMEVQ SKYYCLAAVA ALLKYVEFIQ NSVYAPKSLK 300
ICFQGSEQTA MIDSSSAQNL ELLINNQDYR NNHTLFGVLN YTKTPGGSRR LRSNILEPLV 360
DIETINMRLD CVQELLQDEE LFFGLQSVIS RFLDTEQLLS VLVQIPKQDT VNAAESKITN 420
LIYLKHTLEL VDPLKIAMKN CNTPLLRAYY GSLEDKRFGI ILEKIKTVIN DDARYMKGCL 480
NMRTQKCYAV RSNINEFLDI ARRTYTEIVD DIAGMISQLG EKYSLPLRTS FSSARGFFIQ 540
MTTDCIALPS DQLPSEFIKI SKVKNSYSFT SADLIKMNER CQESLREIYH MTYMIVCKLL 600
SEIYEHIHCL YKLSDTVSML DMLLSFAHAC TLSDYVRPEF TDTLAIKQGW HPILEKISAE 660
KPIANNTYVT EGSNFLIITG PNMSGKSTYL KQIALCQIMA QIGSYVPAEY SSFRIAKQIF 720
TRISTDDDIE TNSSTFMKEM KEIAYILHNA NDKSLILIDE LGRGTNTEEG IGICYAVCEY 780
LLSLKAFTLF ATHFLELCHI DALYPNVENM HFEVQHVKNT SRNKEAILYT YKLSKGLTEE 840
KNYGLKAAEV SSLPPSIVLD AKEITTQITR QILQNQRSTP EMERQRAVYH LATRLVQTAR 900
NSQLDPDSLR IYLSNLKKKY KEDFPRTEQV PEKTEE 937
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0469--Meiosis
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR000432--DNA_mismatch_repair_MutS_C
IPR007861--DNA_mismatch_repair_MutS_clamp
IPR007696--DNA_mismatch_repair_MutS_core
IPR007860--DNA_mmatch_repair_MutS_con_dom
IPR027417--P-loop_NTPase
PROSITE

PS00486--DNA_MISMATCH_REPAIR_2
Pfam

PF05188--MutS_II
PF05192--MutS_III
PF05190--MutS_IV
PF00488--MutS_V
Gene Ontology

GO:0000228--C:nuclear chromosome
GO:0005634--C:nucleus
GO:0000795--C:synaptonemal complex
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0030983--F:mismatched DNA binding
GO:0051026--P:chiasma assembly
GO:0007292--P:female gamete generation
GO:0045143--P:homologous chromosome segregation
GO:0006298--P:mismatch repair
GO:0001541--P:ovarian follicle development
GO:0007131--P:reciprocal meiotic recombination
GO:0007283--P:spermatogenesis