dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000968
Uniprot Accession O15455; TLR3_HUMAN; B2RAI7; B7Z7K0; E6Y0F0; E6Y0F1; E9PGH4; Q4VAL2; Q504W0;
Genbank Protein ID NP_003256.1;
Genbank Nucleotide ID NM_003265.2;
Protein Name Toll-like receptor 3
Protein Synonyms/Alias
Gene Name TLR3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
72RLPAANFTRYSQLTSPhosphoSitePlus22135298
205SLKKLELSSNQIKEFdbPTM 3.0;HPRD 9;PhosphoSitePlus18452278; 16381945; 23193290; 18988627; 22135298
206LKKLELSSNQIKEFSdbPTM 3.0;HPRD 9;PhosphoSitePlus18452278; 16381945; 23193290; 18988627; 22135298
350LPKIDDFSFQWLKCLPhosphoSitePlus22135298
383TGLINLKYLSLSNSFPhosphoSitePlus22135298
391LSLSNSFTSLRTLTNPhosphoSitePlus22135298
392SLSNSFTSLRTLTNEPhosphoSitePlus22135298
759EQFEYAAYIIHAYKDdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated17178723; 16381945; 23193290; 12509442; 22135298; 22817900
818RKIIFVITHHLLKDPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20058876; 16381945; 23193290; 18988627; 22135298; 22817900
858FLEEIPDYKLNHALCdbPTM 3.0;PhosphoSitePlus;UniProt17178723; 16381945; 23193290; 22135298
Sequence
(Fasta)		MRQTLPCIYF WGGLLPFGML CASSTTKCTV SHEVADCSHL KLTQVPDDLP TNITVLNLTH 60
NQLRRLPAAN FTRYSQLTSL DVGFNTISKL EPELCQKLPM LKVLNLQHNE LSQLSDKTFA 120
FCTNLTELHL MSNSIQKIKN NPFVKQKNLI TLDLSHNGLS STKLGTQVQL ENLQELLLSN 180
NKIQALKSEE LDIFANSSLK KLELSSNQIK EFSPGCFHAI GRLFGLFLNN VQLGPSLTEK 240
LCLELANTSI RNLSLSNSQL STTSNTTFLG LKWTNLTMLD LSYNNLNVVG NDSFAWLPQL 300
EYFFLEYNNI QHLFSHSLHG LFNVRYLNLK RSFTKQSISL ASLPKIDDFS FQWLKCLEHL 360
NMEDNDIPGI KSNMFTGLIN LKYLSLSNSF TSLRTLTNET FVSLAHSPLH ILNLTKNKIS 420
KIESDAFSWL GHLEVLDLGL NEIGQELTGQ EWRGLENIFE IYLSYNKYLQ LTRNSFALVP 480
SLQRLMLRRV ALKNVDSSPS PFQPLRNLTI LDLSNNNIAN INDDMLEGLE KLEILDLQHN 540
NLARLWKHAN PGGPIYFLKG LSHLHILNLE SNGFDEIPVE VFKDLFELKI IDLGLNNLNT 600
LPASVFNNQV SLKSLNLQKN LITSVEKKVF GPAFRNLTEL DMRFNPFDCT CESIAWFVNW 660
INETHTNIPE LSSHYLCNTP PHYHGFPVRL FDTSSCKDSA PFELFFMINT SILLIFIFIV 720
LLIHFEGWRI SFYWNVSVHR VLGFKEIDRQ TEQFEYAAYI IHAYKDKDWV WEHFSSMEKE 780
DQSLKFCLEE RDFEAGVFEL EAIVNSIKRS RKIIFVITHH LLKDPLCKRF KVHHAVQQAI 840
EQNLDSIILV FLEEIPDYKL NHALCLRRGM FKSHCILNWP VQKERIGAFR HKLQVALGSK 900
NSVH 905
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000483--Cys-rich_flank_reg_C
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR000372--LRRNT
IPR000157--TIR_dom
IPR027173--TLR3
PROSITE

PS51450--LRR
PS50104--TIR
Pfam

PF00560--LRR_1
PF13855--LRR_8
PF01582--TIR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0036020--C:endolysosome membrane
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0003725--F:double-stranded RNA binding
GO:0042802--F:identical protein binding
GO:0004872--F:receptor activity
GO:0004888--F:transmembrane signaling receptor activity
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0006915--P:apoptotic process
GO:0071260--P:cellular response to mechanical stimulus
GO:0042742--P:defense response to bacterium
GO:0051607--P:defense response to virus
GO:0009597--P:detection of virus
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0006972--P:hyperosmotic response
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0007252--P:I-kappaB phosphorylation
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0097527--P:necroptotic signaling pathway
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0045080--P:positive regulation of chemokine biosynthetic process
GO:0032722--P:positive regulation of chemokine production
GO:0010628--P:positive regulation of gene expression
GO:0050729--P:positive regulation of inflammatory response
GO:0045356--P:positive regulation of interferon-alpha biosynthetic process
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0032728--P:positive regulation of interferon-beta production
GO:0045078--P:positive regulation of interferon-gamma biosynthetic process
GO:0032735--P:positive regulation of interleukin-12 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0034123--P:positive regulation of toll-like receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0034346--P:positive regulation of type III interferon production
GO:0012501--P:programmed cell death
GO:0002730--P:regulation of dendritic cell cytokine production
GO:0043330--P:response to exogenous dsRNA
GO:0007165--P:signal transduction
GO:0034138--P:toll-like receptor 3 signaling pathway
GO:0034142--P:toll-like receptor 4 signaling pathway
GO:0002224--P:toll-like receptor signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway