dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000967
Uniprot Accession O15446; RPA34_HUMAN; Q32N11; Q7Z5U2; Q9UPF6;
Genbank Protein ID NP_001284519.1; NP_036231.1;
Genbank Nucleotide ID NM_001297590.1; NM_012099.1;
Protein Name DNA-directed RNA polymerase I subunit RPA34
Protein Synonyms/Alias A34.5;Antisense to ERCC-1 protein;ASE-1;CD3-epsilon-associated protein;CAST;CD3E-associated protein;RNA polymerase I-associated factor PAF49;
Gene Name CD3EAP
Gene Synonyms/Alias ASE1;CAST;PAF49;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation.
Phosphorylation Sites
 dbPAF PTMs: 36 (View all)
PositionPeptidesSourceReferences ( PMIDs )
25FTAKPPASESPRFSLcurated25627689; 23898821
27AKPPASESPRFSLEAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
64NGRHVPLSGSQIVKGdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558; 25627689
66RHVPLSGSQIVKGKLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
80LAGKRHRYRVLSSCPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated16809778; 16381945; 23193290; 10373416; 18988627; 22135298;
124ILEGPQQSLSGSPLQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 17081983; 18988627; 22135298;
126EGPQQSLSGSPLQPIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 17081983; 18988627; 21081558;
128PQQSLSGSPLQPIPAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 19415658; 19690332;
136PLQPIPASPPPQIPPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 19690332; 16381945; 23193290; 17081983;
159FGGNPPVTGPRSALAPhosphoSitePlus;curated22135298; 25627689; 22199227
163PPVTGPRSALAPNLLPhosphoSitePlus;curated22135298; 25627689
171ALAPNLLTSGKKKKEdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated19276368; 16381945; 23193290; 20068231; 18988627; 21081558;
172LAPNLLTSGKKKKEMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 18669648; 16381945; 23193290; 19276368; 19664995;
205EVDMALGSPEMDVRKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
248PLGVLFPSTTKKRKKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
249LGVLFPSTTKKRKKPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;curated18669648; 16381945; 23193290; 20068231; 18988627; 21081558;
250GVLFPSTTKKRKKPKcurated25627689
276VKQEQINTEPLEDTVdbPTM 3.0;PhosphoSitePlus;curated20815410; 16381945; 23193290; 22135298; 23090842
282NTEPLEDTVLSPTKKdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated19664995; 16381945; 23193290; 20068231; 18988627; 21081558;
285PLEDTVLSPTKKRKRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 19690332; 16381945; 23193290; 17081983;
Sequence
(Fasta)		MEEPQAGDAA RFSCPPNFTA KPPASESPRF SLEALTGPDT ELWLIQAPAD FAPECFNGRH 60
VPLSGSQIVK GKLAGKRHRY RVLSSCPQAG EATLLAPSTE AGGGLTCASA PQGTLRILEG 120
PQQSLSGSPL QPIPASPPPQ IPPGLRPRFC AFGGNPPVTG PRSALAPNLL TSGKKKKEMQ 180
VTEAPVTQEA VNGHGALEVD MALGSPEMDV RKKKKKKNQQ LKEPEAAGPV GTEPTVETLE 240
PLGVLFPSTT KKRKKPKGKE TFEPEDKTVK QEQINTEPLE DTVLSPTKKR KRQKGTEGME 300
PEEGVTVESQ PQVKVEPLEE AIPLPPTKKR KKEKGQMAMM EPGTEAMEPV EPEMKPLESP 360
GGTMAPQQPE GAKPQAQAAL AAPKKKTKKE KQQDATVEPE TEVVGPELPD DLEPQAAPTS 420
TKKKKKKKER GHTVTEPIQP LEPELPGEGQ PEARATPGST KKRKKQSQES RMPETVPQEE 480
MPGPPLNSES GEEAPTGRDK KRKQQQQQPV 511
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0240--DNA-directed RNA polymerase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0832--Ubl conjugation
Interpro

IPR013240--DNA-dir_RNA_pol1_su_RPA34
PROSITE
Pfam

PF08208--RNA_polI_A34
Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005736--C:DNA-directed RNA polymerase I complex
GO:0005739--C:mitochondrion
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000120--C:RNA polymerase I transcription factor complex
GO:0003899--F:DNA-directed RNA polymerase activity
GO:0044822--F:poly(A) RNA binding
GO:0010467--P:gene expression
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0040029--P:regulation of gene expression, epigenetic
GO:0009303--P:rRNA transcription
GO:0006363--P:termination of RNA polymerase I transcription
GO:0006362--P:transcription elongation from RNA polymerase I promoter
GO:0006360--P:transcription from RNA polymerase I promoter
GO:0006361--P:transcription initiation from RNA polymerase I promoter
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway