| Tag |
Content |
| dbPAF ID |
dbPAF-0000966 |
| Uniprot Accession |
O15444; CCL25_HUMAN; A1L4J4; A6NI52; A8K9E7; B5MCA5; Q96KJ7;
|
| Genbank Protein ID |
NP_001188288.1; NP_005615.2; XP_011526479.1;
|
| Genbank Nucleotide ID |
NM_001201359.1; NM_005624.3; XM_011528177.1;
|
| Protein Name |
C-C motif chemokine 25 |
| Protein Synonyms/Alias |
Chemokine TECK;Small-inducible cytokine A25;Thymus-expressed chemokine; |
| Gene Name |
CCL25 |
| Gene Synonyms/Alias |
SCYA25;TECK; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.Functional Description
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR IQEVSGSCNL 60
PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL HHNTQTFQAG PHAVKKLSSG 120
NSKLSSSKFS NPISSSKRNV SLLISANSGL
151Fasta Sequence
>O15444|CCL25|Homo sapiens(Human)
MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL
|
| Keyword |
KW-0025--Alternative splicing
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0202--Cytokine
KW-1015--Disulfide bond
KW-0395--Inflammatory response
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR001811--Chemokine_IL8-like_dom
|
| PROSITE |
|
| Pfam |
PF00048--IL8
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0031735--F:CCR10 chemokine receptor binding
GO:0008009--F:chemokine activity
GO:0042379--F:chemokine receptor binding
GO:0005179--F:hormone activity
GO:0060326--P:cell chemotaxis
GO:0007166--P:cell surface receptor signaling pathway
GO:0071346--P:cellular response to interferon-gamma
GO:0071347--P:cellular response to interleukin-1
GO:0071356--P:cellular response to tumor necrosis factor
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0048247--P:lymphocyte chemotaxis
GO:0002548--P:monocyte chemotaxis
GO:1903237--P:negative regulation of leukocyte tethering or rolling
GO:0030593--P:neutrophil chemotaxis
GO:0001954--P:positive regulation of cell-matrix adhesion
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043547--P:positive regulation of GTPase activity
|
