dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000965
Uniprot Accession O15440; MRP5_HUMAN; B9EIQ2; O14517; Q29ZA9; Q29ZB1; Q86UX3; Q86W30; Q9UN85; Q9UNP5; Q9UQC3;
Genbank Protein ID NP_001018881.1; NP_005679.2; XP_005247115.1; XP_005247116.1; XP_011510616.1;
Genbank Nucleotide ID NM_001023587.1; NM_005688.2; XM_005247058.3; XM_005247059.3; XM_011512314.1;
Protein Name Multidrug resistance-associated protein 5
Protein Synonyms/Alias ATP-binding cassette sub-family C member 5;Multi-specific organic anion transporter C;MOAT-C;SMRP;pABC11;
Gene Name ABCC5
Gene Synonyms/Alias MRP5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Phosphorylation Sites
 dbPAF PTMs: 28 (View all)
PositionPeptidesSourceReferences ( PMIDs )
10DIDIGKEYIIPSPGYdbPTM 3.0;PhosphoSitePlus;curated18180459; 16381945; 23193290; 22135298; 25627689; 22817900
14GKEYIIPSPGYRSVRPhosphoSitePlus;curated22135298; 25627689; 23917254; 24961811
17YIIPSPGYRSVRERTPhosphoSitePlus;curated22135298; 25627689
19IPSPGYRSVRERTSTPhosphoSitePlus;curated22135298; 25627689; 23186163; 26074081; 24961811
60AARAEGLSLDASMHSPhosphoSitePlus;curated22135298; 23186163
64EGLSLDASMHSQLRIPhosphoSitePlus22135298
67SLDASMHSQLRILDEPhosphoSitePlus22135298
351RRKCVAATDERVQKMPhosphoSitePlus22135298
485MIKNKPASPHIKIEMPhosphoSitePlus;curated22135298; 25627689
501NATLAWDSSHSSIQNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 17081983; 18988627; 21081558;
502ATLAWDSSHSSIQNSdbPTM 3.0;HPRD 9;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 19366988; 25627689;
504LAWDSSHSSIQNSPKdbPTM 3.0;HPRD 9;PHOSIDA;SysPTM 2.0;curated17081983; 19651622; 16381945; 23193290; 18988627; 21081558;
505AWDSSHSSIQNSPKLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20068231; 19651622; 18988627;
509SHSSIQNSPKLTPKMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 19276368; 20068231; 20363803;
513IQNSPKLTPKMKKDKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 20068231; 22115753; 18988627;
553KGHLLLDSDERPSPEPhosphoSitePlus;curated22135298; 25627689
558LDSDERPSPEEEEGKdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 25850435; 25627689;
686GERGANLSGGQRQRIdbPTM 3.0;PhosphoSitePlus;curated20363803; 21406692; 16381945; 23193290; 22135298
800EINSKKETSGSQKKSPhosphoSitePlus22135298
807TSGSQKKSQDKGPKTPhosphoSitePlus22135298
Sequence
(Fasta)		MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS 60
LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR 120
VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 180
LSIVCLMITQ LAGFSGPAFM VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW 240
ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA TDERVQKMNE 360
VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS ITVGVAPIVV VIASVVTFSV 420
HMTLGFDLTA AQAFTVVTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK 480
NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA 540
VLAEQKGHLL LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG 600
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD EERYNSVLNS 660
CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG 720
NHIFNSAIRK HLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI 780
FNNLLLGETP PVEINSKKET SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS 840
VPWSVYGVYI QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS 900
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE LFRRILRSPM 960
KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV FFCVGMIAGV FPWFLVAVGP 1020
LVILFSVLHI VSRVLIRELK RLDNITQSPF LSHITSSIQG LATIHAYNKG QEFLHRYQEL 1080
LDDNQAPFFL FTCAMRWLAV RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT 1140
GLFQFTVRLA SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM 1200
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC IKIDGVRISD 1260
IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW DALERTHMKE CIAQLPLKLE 1320
SEVMENGDNF SVGERQLLCI ARALLRHCKI LILDEATAAM DTETDLLIQE TIREAFADCT 1380
MLTIAHRLHT VLGSDRIMVL AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG 1438
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030238--ABCC5
IPR027417--P-loop_NTPase
PROSITE

PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
Pfam

PF00664--ABC_membrane
PF00005--ABC_tran
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0008514--F:organic anion transmembrane transporter activity
GO:0005975--P:carbohydrate metabolic process
GO:0030203--P:glycosaminoglycan metabolic process
GO:0030213--P:hyaluronan biosynthetic process
GO:0030212--P:hyaluronan metabolic process
GO:0044281--P:small molecule metabolic process
GO:0055085--P:transmembrane transport
GO:0006810--P:transport