dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000964
Uniprot Accession O15439; MRP4_HUMAN; A9Z1Z7; B7Z3Q7; Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2;
Genbank Protein ID NP_001098985.1; NP_001288758.1; NP_001288759.1; NP_005836.2;
Genbank Nucleotide ID NM_001105515.2; NM_001301829.1; NM_001301830.1; NM_005845.4;
Protein Name Multidrug resistance-associated protein 4
Protein Synonyms/Alias ATP-binding cassette sub-family C member 4;MRP/cMOAT-related ABC transporter;Multi-specific organic anion transporter B;MOAT-B;
Gene Name ABCC4
Gene Synonyms/Alias MRP4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be an organic anion pump relevant to cellular detoxification.
Phosphorylation Sites
 dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
45RLEEDDMYSVLPEDRPhosphoSitePlus22135298
182YRKALRLSNMAMGKTPhosphoSitePlus22135298
313EISKILRSSCLRGMNdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
314ISKILRSSCLRGMNLdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
388VSIRRIQTFLLLDEIPhosphoSitePlus22135298
404QRNRQLPSDGKKMVHdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298
601LQYLKAASQILILKDdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18491316; 16381945; 23193290; 18988627; 22135298; 19366988;
623TYTEFLKSGIDFGSLPHOSIDA21081558
629KSGIDFGSLLKKDNEPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25850435; 24961811
646EQPPVPGTPTLRNRTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19690332; 16381945; 23193290; 19664994;
648PPVPGTPTLRNRTFSdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 19651622; 20068231; 18988627;
653TPTLRNRTFSESSVWPhosphoSitePlus;curated22135298; 23898821; 23090842
655TLRNRTFSESSVWSQPhosphoSitePlus;curated22135298; 25850435; 25627689; 23898821; 24961811
661FSESSVWSQQSSRPSPhosphoSitePlus;curated22135298; 23090842
664SSVWSQQSSRPSLKDPhosphoSitePlus;curated22135298; 25627689; 23917254
665SVWSQQSSRPSLKDGcurated25627689; 24961811
668SQQSSRPSLKDGALEPhosphoSitePlus;curated22135298; 25627689; 23917254; 24961811
676LKDGALESQDTENVPPhosphoSitePlus22135298
687ENVPVTLSEENRSEGcurated25627689
692TLSEENRSEGKVGFQcurated25627689; 24961811
Sequence
(Fasta)		MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL 60
QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF 120
ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR 180
LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG 240
MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT 300
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA 360
VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD 420
KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ 480
QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK 540
ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA 600
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW 660
SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKNYFRAGAH WIVFIFLILL 720
NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTEKLD LNWYLGIYSG LTVATVLFGI 780
ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF 840
LDFIQTLLQV VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV 900
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAMFV 960
IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS AEVENMMISV ERVIEYTDLE 1020
KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY SPGGPLVLKH LTALIKSQEK VGIVGRTGAG 1080
KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE 1140
HTDEELWNAL QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII 1200
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG RLKEYDEPYV 1260
LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI GHTDHMVTNT SNGQPSTLTI 1320
FETAL 1326
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030240--ABCC4
IPR027417--P-loop_NTPase
PROSITE

PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
Pfam

PF00664--ABC_membrane
PF00005--ABC_tran
Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0031088--C:platelet dense granule membrane
GO:0016404--F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0007596--P:blood coagulation
GO:0055114--P:oxidation-reduction process
GO:0030168--P:platelet activation
GO:0002576--P:platelet degranulation
GO:0055085--P:transmembrane transport