dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000963
Uniprot Accession O15438; MRP3_HUMAN; B2RPA9; D3DTX9; O60265; O60922; O75621; O95078; O95289; O95290; Q86X85; Q9UN52;
Genbank Protein ID NP_001137542.1; NP_003777.2;
Genbank Nucleotide ID NM_001144070.1; NM_003786.3;
Protein Name Canalicular multispecific organic anion transporter 2
Protein Synonyms/Alias ATP-binding cassette sub-family C member 3;Multi-specific organic anion transporter D;MOAT-D;Multidrug resistance-associated protein 3;
Gene Name ABCC3
Gene Synonyms/Alias CMOAT2;MLP2;MRP3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
229WFTKMAIYGYRHPLEPhosphoSitePlus22135298
231TKMAIYGYRHPLEEKPhosphoSitePlus22135298
281AAPGKNASGEDEVLLPhosphoSitePlus;curated22135298; 23898821; 20071362; 25849741
486KQMKLKDSRIKLMSEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
668GPVGCGKSSLVSALLPhosphoSitePlus22135298
720KALNPKRYQQTLEACPhosphoSitePlus22135298
882EALLIEDTLSNHTDLPhosphoSitePlus22135298
884LLIEDTLSNHTDLTDPhosphoSitePlus22135298
896LTDNDPVTYVVQKQFPhosphoSitePlus22135298
908KQFMRQLSALSSDGEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 19651622; 18988627; 21081558;
911MRQLSALSSDGEGQGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 19651622; 17081983; 18988627;
912RQLSALSSDGEGQGRdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 22135298; 19366988; 23898821
1248NWMIRMMSDLESNIVdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
1470LIQATIRTQFDTCTVdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558
Sequence
(Fasta)		MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP CYLLYLRHHC 60
RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA PAPVFFVTPL VVGVTMLLAT 120
LLIQYERLQG VQSSGVLIIF WFLCVVCAIV PFRSKILLAK AEGEISDPFR FTTFYIHFAL 180
VLSALILACF REKPPFFSAK NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL 240
WSLKEEDRSQ MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL 300
KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF LVAGLMFLCS 360
MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV KRASTVGEIV NLMSVDAQRF 420
MDLAPFLNLL WSAPLQIILA IYFLWQNLGP SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ 480
MKLKDSRIKL MSEILNGIKV LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM 540
CSPFLVTLIT LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK 600
RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ VPKGALVAVV 660
GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI QNCTLQENVL FGKALNPKRY 720
QQTLEACALL ADLEMLPGGD QTEIGEKGIN LSGGQRQRVS LARAVYSDAD IFLLDDPLSA 780
VDSHVAKHIF DHVIGPEGVL AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ 840
RNGSFANFLC NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ 900
KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA IGTVELSVFW 960
DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM ADSRQNNTSL RLGVYAALGI 1020
LQGFLVMLAA MAMAAGGIQA ARVLHQALLH NKIRSPQSFF DTTPSGRILN CFSKDIYVVD 1080
EVLAPVILML LNSFFNAIST LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE 1140
SVSRSPIYSH FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE 1200
FVGNCVVLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL ESNIVAVERV 1260
KEYSKTETEA PWVVEGSRPP EGWPPRGEVE FRNYSVRYRP GLDLVLRDLS LHVHGGEKVG 1320
IVGRTGAGKS SMTLCLFRIL EAAKGEIRID GLNVADIGLH DLRSQLTIIP QDPILFSGTL 1380
RMNLDPFGSY SEEDIWWALE LSHLHTFVSS QPAGLDFQCS EGGENLSVGQ RQLVCLARAL 1440
LRKSRILVLD EATAAIDLET DNLIQATIRT QFDTCTVLTI AHRLNTIMDY TRVLVLDKGV 1500
VAEFDSPANL IAARGIFYGM ARDAGLA 1528
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR011527--ABC1_TM_dom
IPR003439--ABC_transporter-like
IPR017871--ABC_transporter_CS
IPR030242--ABCC3
IPR005292--Multidrug-R_assoc
IPR027417--P-loop_NTPase
PROSITE

PS50929--ABC_TM1F
PS00211--ABC_TRANSPORTER_1
PS50893--ABC_TRANSPORTER_2
Pfam

PF00664--ABC_membrane
PF00005--ABC_tran
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0042626--F:ATPase activity, coupled to transmembrane movement of substances
GO:0008514--F:organic anion transmembrane transporter activity
GO:0015721--P:bile acid and bile salt transport
GO:0008206--P:bile acid metabolic process
GO:0044281--P:small molecule metabolic process
GO:0055085--P:transmembrane transport
GO:0006810--P:transport