dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000961
Uniprot Accession O15431; COPT1_HUMAN; A8K8Z6; Q53GR5; Q5T1M4;
Genbank Protein ID NP_001850.1;
Genbank Nucleotide ID NM_001859.3;
Protein Name High affinity copper uptake protein 1
Protein Synonyms/Alias Copper transporter 1;hCTR1;Solute carrier family 31 member 1;
Gene Name SLC31A1
Gene Synonyms/Alias COPT1;CTR1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
High-affinity, saturable copper transporter involved in dietary copper uptake.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
4----MDHSHHMGMSYPhosphoSitePlus22135298
10HSHHMGMSYMDSNSTPhosphoSitePlus22135298
11SHHMGMSYMDSNSTMPhosphoSitePlus22135298
92GLKIARESLLRKSQVcurated24702127
105QVSIRYNSMPVPGPNPhosphoSitePlus22135298
114PVPGPNGTILMETHKPhosphoSitePlus;curated22135298; 25627689; 23186163
Sequence
(Fasta)
MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG 60
LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS IRYNSMPVPG PNGTILMETH 120
KTVGQQMLSF PHLLQTVLHI IQVVISYFLM LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA 180
VVVDITEHCH 191
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0186--Copper
KW-0187--Copper transport
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport

Interpro

IPR007274--Cop_transporter

PROSITE
Pfam

PF04145--Ctr

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005770--C:late endosome
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0055037--C:recycling endosome
GO:0005375--F:copper ion transmembrane transporter activity
GO:0015088--F:copper uptake transmembrane transporter activity
GO:0006878--P:cellular copper ion homeostasis
GO:0072719--P:cellular response to cisplatin
GO:1902861--P:copper ion import into cell
GO:0006825--P:copper ion transport
GO:0006855--P:drug transmembrane transport
GO:0055085--P:transmembrane transport