dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000959
Uniprot Accession O15427; MOT4_HUMAN; B3KXG8; Q2M1P8;
Genbank Protein ID NP_001035887.1; NP_001035888.1; NP_001193879.1; NP_001193880.1; NP_001193881.1; NP_004198.1; XP_011521909.1;
Genbank Nucleotide ID NM_001042422.2; NM_001042423.2; NM_001206950.1; NM_001206951.1; NM_001206952.1; NM_004207.3; XM_011523607.1;
Protein Name Monocarboxylate transporter 4
Protein Synonyms/Alias
Gene Name SLC16A3
Gene Synonyms/Alias MCT4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
35CFVITGFSYAFPKAVPhosphoSitePlus22135298
36FVITGFSYAFPKAVSPhosphoSitePlus22135298
436LHKPPADSGVDLREVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18578522; 20068231; 19651622;
460KNGEVVHTPETSV--dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 18691976; 16381945; 23193290; 16964243;
463EVVHTPETSV-----dbPTM 3.0;HPRD 9;PHOSIDA;SysPTM 2.0;curated20068231; 16381945; 23193290; 17081983; 18988627; 21081558;
464VVHTPETSV------dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 18691976; 16381945; 23193290; 16964243;
Sequence
(Fasta)		MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT 60
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV 120
ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF 180
LILGGLLLNC CVCAALMRPL VVTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL 240
GLFVPPVFVV SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF 300
SMFFNGLADL AGSTAGDYGG LVVFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL 360
LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE 420
VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEVVHT PETSV 466
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR004743--MCT
IPR030756--MCT4
IPR011701--MFS
IPR020846--MFS_dom
PROSITE

PS50850--MFS
Pfam

PF07690--MFS_1
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0031965--C:nuclear membrane
GO:0005886--C:plasma membrane
GO:0015129--F:lactate transmembrane transporter activity
GO:0008028--F:monocarboxylic acid transmembrane transporter activity
GO:0044822--F:poly(A) RNA binding
GO:0015293--F:symporter activity
GO:0007596--P:blood coagulation
GO:0044237--P:cellular metabolic process
GO:0050900--P:leukocyte migration
GO:0015718--P:monocarboxylic acid transport
GO:0035879--P:plasma membrane lactate transport
GO:0006090--P:pyruvate metabolic process
GO:0044281--P:small molecule metabolic process
GO:0055085--P:transmembrane transport