dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000956 | ||||||||||||
| Uniprot Accession | O15405; TOX3_HUMAN; B4DRD0; B5MCW4; | ||||||||||||
| Genbank Protein ID | NP_001073899.2; NP_001139660.1; | ||||||||||||
| Genbank Nucleotide ID | NM_001080430.2; NM_001146188.1; | ||||||||||||
| Protein Name | TOX high mobility group box family member 3 | ||||||||||||
| Protein Synonyms/Alias | CAG trinucleotide repeat-containing gene F9 protein;Trinucleotide repeat-containing gene 9 protein; | ||||||||||||
| Gene Name | TOX3 | ||||||||||||
| Gene Synonyms/Alias | CAGF9;TNRC9; | ||||||||||||
| Organism | Homo sapiens(Human) | ||||||||||||
| NCBI Taxa ID | 9606 | ||||||||||||
| Functional Description (View all) |
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MDVRFYPAAA GDPASLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS EQTFHTPSLG 60 DEEFEIPPIT PPPESDPALG MPDVLLPFQA LSDPLPSQGS EFTPQFPPQS LDLPSITISR 120 NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP SLIMRSIVHM TDAARSGVMP PAQLTTINQS 180 QLSAQLGLNL GGASMPHTSP SPPASKSATP SPSSSINEED ADEANRAIGE KRAAPDSGKK 240 PKTPKKKKKK DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ 300 KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST NLTSSLLLNT 360 PLSQHGTVSA SPQTLQQSLP RSIAPKPLTM RLPMNQIVTS VTIAANMPSN IGAPLISSMG 420 TTMVGSAPST QVSPSVQTQQ HQMQLQQQQQ QQQQQMQQMQ QQQLQQHQMH QQIQQQMQQQ 480 HFQHHMQQHL QQQQQHLQQQ INQQQLQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVASQI 540 TSPIPAIGSP QPASQQHQSQ IQSQTQTQVL SQVSIF 577 |
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| Keyword | KW-0010--Activator |
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| Interpro | IPR009071--HMG_box_dom |
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| PROSITE | PS50118--HMG_BOX_2 |
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| Pfam | PF00505--HMG_box |
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| Gene Ontology | GO:0005634--C:nucleus |