dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000955
Uniprot Accession O15403; MOT7_HUMAN; Q6P1X3;
Genbank Protein ID NP_001167637.1; NP_004685.2; XP_011523763.1;
Genbank Nucleotide ID NM_001174166.1; NM_004694.4; XM_011525461.1;
Protein Name Monocarboxylate transporter 7
Protein Synonyms/Alias
Gene Name SLC16A6
Gene Synonyms/Alias MCT6;MCT7;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
224ENRKEAQYMLENEKTPhosphoSitePlus;curated22135298; 25627689; 24961811
231YMLENEKTRTSIDSIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;SysPTM 2.0;curated18669648; 17081983; 16381945; 23193290; 18988627; 21081558;
233LENEKTRTSIDSIDSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;SysPTM 2.0;curated18669648; 16381945; 23193290; 17081983; 18988627; 19366988;
234ENEKTRTSIDSIDSGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 17081983; 18988627; 19060867;
237KTRTSIDSIDSGVELdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 18988627; 21081558;
240TSIDSIDSGVELTTSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 18988627; 21081558;
245IDSGVELTTSPKNVPPhosphoSitePlus;curated22135298; 25627689
246DSGVELTTSPKNVPTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 25627689; 22817900
247SGVELTTSPKNVPTHdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 18691976; 16381945; 23193290; 18988627; 21081558;
273QQVLVKTSPRPSEKKPhosphoSitePlus22135298
277VKTSPRPSEKKAPLLPhosphoSitePlus22135298
312TLGFFAPSLYIIPLGcurated26074081
314GFFAPSLYIIPLGIScurated26074081
Sequence
(Fasta)		MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN DLMDSFNESN 60
SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL VSTGMVAASF SQEVSHMYVA 120
IGIISGLGYC FSFLPTVTIL SQYFGKRRSI VTAVASTGEC FAVFAFAPAI MALKERIGWR 180
YSLLFVGLLQ LNIVIFGALL RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS 240
GVELTTSPKN VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF 300
GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV LNREPIRKIY 360
IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG GTHIPLLAED DVVGIEKMSS 420
AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ 480
HHHSGETKVV SHRGKTLQDI PEDFLEMDLA KNEHRVHVQM EPV 524
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR030766--MCT7
IPR011701--MFS
IPR020846--MFS_dom
PROSITE

PS50850--MFS
Pfam

PF07690--MFS_1
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0008028--F:monocarboxylic acid transmembrane transporter activity
GO:0015293--F:symporter activity
GO:0034220--P:ion transmembrane transport
GO:0015718--P:monocarboxylic acid transport