dbPAF Protein Information
Tag | Content | ||||||||||||||||||||
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dbPAF ID | dbPAF-0000950 | ||||||||||||||||||||
Uniprot Accession | O15393; TMPS2_HUMAN; A8K6Z8; B2R8E5; B7Z459; D3DSJ2; F8WES1; Q6GTK7; Q9BXX1; | ||||||||||||||||||||
Genbank Protein ID | NP_001128571.1; NP_005647.3; XP_011528033.1; | ||||||||||||||||||||
Genbank Nucleotide ID | NM_001135099.1; NM_005656.3; XM_011529731.1; | ||||||||||||||||||||
Protein Name | Transmembrane protease serine 2 | ||||||||||||||||||||
Protein Synonyms/Alias | Serine protease 10; | ||||||||||||||||||||
Gene Name | TMPRSS2 | ||||||||||||||||||||
Gene Synonyms/Alias | PRSS10; | ||||||||||||||||||||
Organism | Homo sapiens(Human) | ||||||||||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||||||||||
Functional Description (View all) |
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. | ||||||||||||||||||||
Phosphorylation Sites |
dbPAF PTMs: 4
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Sequence (Fasta) | MALNSGSPPA IGPYYENHGY QPENPYPAQP TVVPTVYEVH PAQYYPSPVP QYAPRVLTQA 60 SNPVVCTQPK SPSGTVCTSK TKKALCITLT LGTFLVGAAL AAGLLWKFMG SKCSNSGIEC 120 DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY 180 GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR 240 CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK 300 PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL 360 VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI 420 TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF 480 TDWIYRQMRA DG 493 |
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Keyword | KW-0025--Alternative splicing |
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Interpro | IPR023415--LDLR_class-A_CS |
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PROSITE | PS01209--LDLRA_1 |
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Pfam | PF00089--Trypsin |
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Gene Ontology | GO:0070062--C:extracellular exosome |