dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000950
Uniprot Accession O15393; TMPS2_HUMAN; A8K6Z8; B2R8E5; B7Z459; D3DSJ2; F8WES1; Q6GTK7; Q9BXX1;
Genbank Protein ID NP_001128571.1; NP_005647.3; XP_011528033.1;
Genbank Nucleotide ID NM_001135099.1; NM_005656.3; XM_011529731.1;
Protein Name Transmembrane protease serine 2
Protein Synonyms/Alias Serine protease 10;
Gene Name TMPRSS2
Gene Synonyms/Alias PRSS10;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
44YEVHPAQYYPSPVPQPhosphoSitePlus22135298
45EVHPAQYYPSPVPQYPhosphoSitePlus22135298
52YPSPVPQYAPRVLTQdbPTM 3.0;PhosphoSitePlus21253578; 16381945; 23193290; 22135298
341HPNYDSKTKNNDIALPhosphoSitePlus22135298
Sequence
(Fasta)
MALNSGSPPA IGPYYENHGY QPENPYPAQP TVVPTVYEVH PAQYYPSPVP QYAPRVLTQA 60
SNPVVCTQPK SPSGTVCTSK TKKALCITLT LGTFLVGAAL AAGLLWKFMG SKCSNSGIEC 120
DSSGTCINPS NWCDGVSHCP GGEDENRCVR LYGPNFILQV YSSQRKSWHP VCQDDWNENY 180
GRAACRDMGY KNNFYSSQGI VDDSGSTSFM KLNTSAGNVD IYKKLYHSDA CSSKAVVSLR 240
CIACGVNLNS SRQSRIVGGE SALPGAWPWQ VSLHVQNVHV CGGSIITPEW IVTAAHCVEK 300
PLNNPWHWTA FAGILRQSFM FYGAGYQVEK VISHPNYDSK TKNNDIALMK LQKPLTFNDL 360
VKPVCLPNPG MMLQPEQLCW ISGWGATEEK GKTSEVLNAA KVLLIETQRC NSRYVYDNLI 420
TPAMICAGFL QGNVDSCQGD SGGPLVTSKN NIWWLIGDTS WGSGCAKAYR PGVYGNVMVF 480
TDWIYRQMRA DG 493
Keyword

KW-0025--Alternative splicing
KW-0068--Autocatalytic cleavage
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0964--Secreted
KW-0720--Serine protease
KW-0735--Signal-anchor
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0865--Zymogen

Interpro

IPR023415--LDLR_class-A_CS
IPR002172--LDrepeatLR_classA_rpt
IPR018114--Peptidase_S1_AS
IPR009003--Peptidase_S1_PA
IPR001314--Peptidase_S1A
IPR001190--SRCR
IPR017448--SRCR-like_dom
IPR001254--Trypsin_dom

PROSITE

PS01209--LDLRA_1
PS50068--LDLRA_2
PS50287--SRCR_2
PS50240--TRYPSIN_DOM
PS00134--TRYPSIN_HIS
PS00135--TRYPSIN_SER

Pfam

PF00089--Trypsin

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005044--F:scavenger receptor activity
GO:0004252--F:serine-type endopeptidase activity
GO:0008236--F:serine-type peptidase activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0016540--P:protein autoprocessing
GO:0006508--P:proteolysis