| Tag |
Content |
| dbPAF ID |
dbPAF-0000949 |
| Uniprot Accession |
O15392; BIRC5_HUMAN; A2SUH6; B2R4R1; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8;
|
| Genbank Protein ID |
NP_001012270.1; NP_001012271.1; NP_001159.2;
|
| Genbank Nucleotide ID |
NM_001012270.1; NM_001012271.1; NM_001168.2;
|
| Protein Name |
Baculoviral IAP repeat-containing protein 5 |
| Protein Synonyms/Alias |
Apoptosis inhibitor 4;Apoptosis inhibitor survivin; |
| Gene Name |
BIRC5 |
| Gene Synonyms/Alias |
API4;IAP4; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.Functional Description
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120
KKEFEETAKK VRRAIEQLAA MD
143Fasta Sequence
>O15392|BIRC5|Homo sapiens(Human)
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0995--Kinetochore
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0678--Repressor
KW-0789--Thiol protease inhibitor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
|
| Interpro |
IPR001370--BIR_rpt
|
| PROSITE |
PS50143--BIR_REPEAT_2
|
| Pfam |
PF00653--BIR
|
| Gene Ontology |
GO:0005814--C:centriole
GO:0032133--C:chromosome passenger complex
GO:0000775--C:chromosome, centromeric region
GO:0000777--C:condensed chromosome kinetochore
GO:0005737--C:cytoplasm
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031021--C:interphase microtubule organizing center
GO:0005874--C:microtubule
GO:0030496--C:midbody
GO:0000228--C:nuclear chromosome
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0005876--C:spindle microtubule
GO:0051087--F:chaperone binding
GO:0050897--F:cobalt ion binding
GO:0048037--F:cofactor binding
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0008017--F:microtubule binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0008536--F:Ran GTPase binding
GO:0015631--F:tubulin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0007059--P:chromosome segregation
GO:0000910--P:cytokinesis
GO:0051303--P:establishment of chromosome localization
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0090307--P:mitotic spindle assembly
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:0031536--P:positive regulation of exit from mitosis
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0031503--P:protein complex localization
GO:0006468--P:protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0009966--P:regulation of signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0031577--P:spindle checkpoint
GO:0006351--P:transcription, DNA-templated
|
