dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000947
Uniprot Accession O15389; SIGL5_HUMAN;
Genbank Protein ID NP_003821.1;
Genbank Nucleotide ID NM_003830.3;
Protein Name Sialic acid-binding Ig-like lectin 5
Protein Synonyms/Alias
Gene Name SIGLEC5
Gene Synonyms/Alias CD33L2;OBBP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
485DEDPIMGTITSGSRKPhosphoSitePlus22135298
487DPIMGTITSGSRKKPPhosphoSitePlus22135298
488PIMGTITSGSRKKPWcurated25003641
490MGTITSGSRKKPWPDPhosphoSitePlus;curated22135298; 25003641
520EEQKELHYASLSFSEPhosphoSitePlus22135298
544EAPSTTEYSEIKTSKdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 21253578; 16381945; 23193290; 19060867; 22135298;
545APSTTEYSEIKTSK-PhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
Sequence
(Fasta)		MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW 60
FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV 120
ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW 180
TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQMKRQGA QVTTERTVQL NVSYAPQTIT 240
IFRNGIALEI LQNTSYLPVL EGQALRLLCD APSNPPAHLS WFQGSPALNA TPISNTGILE 300
LRRVRSAEEG GFTCRAQHPL GFLQIFLNLS VYSLPQLLGP SCSWEAEGLH CRCSFRARPA 360
PSLCWRLEEK PLEGNSSQGS FKVNSSSAGP WANSSLILHG GLSSDLKVSC KAWNIYGSQS 420
GSVLLLQGRS NLGTGVVPAA LGGAGVMALL CICLCLIFFL IVKARRKQAA GRPEKMDDED 480
PIMGTITSGS RKKPWPDSPG DQASPPGDAP PLEEQKELHY ASLSFSEMKS REPKDQEAPS 540
TTEYSEIKTS K 552
Keyword

KW-0002--3D-structure
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0430--Lectin
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR003598--Ig_sub2
IPR013106--Ig_V-set
PROSITE

PS50835--IG_LIKE
PS00290--IG_MHC
Pfam

PF07686--V-set
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0030246--F:carbohydrate binding
GO:0007155--P:cell adhesion