| Tag |
Content |
| dbPAF ID |
dbPAF-0000946 |
| Uniprot Accession |
O15382; BCAT2_HUMAN; B2RB87; O00269; Q96KG1; Q9BTB6; Q9BUU6;
|
| Genbank Protein ID |
NP_001158245.1; NP_001181.2; NP_001271254.1;
|
| Genbank Nucleotide ID |
NM_001164773.1; NM_001190.3; NM_001284325.1;
|
| Protein Name |
Branched-chain-amino-acid aminotransferase, mitochondrial |
| Protein Synonyms/Alias |
|
| Gene Name |
BCAT2 |
| Gene Synonyms/Alias |
BCATM;BCT2;ECA40; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.Functional Description
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MAAAALGQIW ARKLLSVPWL LCGPRRYASS SFKAADLQLE MTQKPHKKPG PGEPLVFGKT 60
FTDHMLMVEW NDKGWGQPRI QPFQNLTLHP ASSSLHYSLQ LFEGMKAFKG KDQQVRLFRP 120
WLNMDRMLRS AMRLCLPSFD KLELLECIRR LIEVDKDWVP DAAGTSLYVR PVLIGNEPSL 180
GVSQPTRALL FVILCPVGAY FPGGSVTPVS LLADPAFIRA WVGGVGNYKL GGNYGPTVLV 240
QQEALKRGCE QVLWLYGPDH QLTEVGTMNI FVYWTHEDGV LELVTPPLNG VILPGVVRQS 300
LLDMAQTWGE FRVVERTITM KQLLRALEEG RVREVFGSGT ACQVCPVHRI LYKDRNLHIP 360
TMENGPELIL RFQKELKEIQ YGIRAHEWMF PV
393Fasta Sequence
>O15382|BCAT2|Homo sapiens(Human)
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0028--Amino-acid biosynthesis
KW-0032--Aminotransferase
KW-0100--Branched-chain amino acid biosynthesis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0496--Mitochondrion
KW-0621--Polymorphism
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0808--Transferase
KW-0809--Transit peptide
|
| Interpro |
IPR001544--Aminotrans_IV
IPR018300--Aminotrans_IV_CS
IPR005786--B_amino_transII
|
| PROSITE |
PS00770--AA_TRANSFER_CLASS_4
|
| Pfam |
PF01063--Aminotran_4
|
| Gene Ontology |
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0004084--F:branched-chain-amino-acid transaminase activity
GO:0052656--F:L-isoleucine transaminase activity
GO:0052654--F:L-leucine transaminase activity
GO:0052655--F:L-valine transaminase activity
GO:0009082--P:branched-chain amino acid biosynthetic process
GO:0009083--P:branched-chain amino acid catabolic process
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0006550--P:isoleucine catabolic process
GO:0006551--P:leucine metabolic process
GO:0010817--P:regulation of hormone levels
GO:0044281--P:small molecule metabolic process
GO:0006573--P:valine metabolic process
|
