dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000945
Uniprot Accession O15381; NVL_HUMAN; B4DMC4; B4DP98; Q96EM7;
Genbank Protein ID NP_001230075.1; NP_001230076.1; NP_002524.2; NP_996671.1;
Genbank Nucleotide ID NM_001243146.1; NM_001243147.1; NM_002533.3; NM_206840.2;
Protein Name Nuclear valosin-containing protein-like
Protein Synonyms/Alias
Gene Name NVL
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). May play a role in 60S ribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053).
Phosphorylation Sites
 dbPAF PTMs: 37 (View all)
PositionPeptidesSourceReferences ( PMIDs )
20LKQRVIQYLTSNKCGdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558
23RVIQYLTSNKCGKYVPhosphoSitePlus22135298
29TSNKCGKYVDIGVLAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
43ASDLQRVYSIDYGRRdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
44SDLQRVYSIDYGRRKcurated22817900
47QRVYSIDYGRRKRNAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
101NEYTESYSDDDSSMEdbPTM 3.018669648; 19007248; 19691289; 20068231; 16381945; 23193290
105ESYSDDDSSMEDYPDdbPTM 3.018669648; 19007248; 19691289; 20068231; 16381945; 23193290
121QSANHMNSSLLSLYRdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
134YRKGNPDSVSNTPEMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19007248; 16381945; 23193290; 20068231; 18988627;
136KGNPDSVSNTPEMEQcurated22199227; 25262027
138NPDSVSNTPEMEQREdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19007248; 16381945; 23193290; 19691289; 20068231;
147EMEQRETTSSTPRISPhosphoSitePlus22135298
149EQRETTSSTPRISSKPhosphoSitePlus;curated22135298; 25627689
150QRETTSSTPRISSKTPhosphoSitePlus;curated22135298; 25627689
159RISSKTGSIPLKTPAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19007248; 16381945; 23193290; 18988627; 22135298; 25627689
164TGSIPLKTPAKDSEGPhosphoSitePlus;curated22135298; 25627689; 23898821
178GGWFIDKTPSVKKDSPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25627689; 26074081
180WFIDKTPSVKKDSFFPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25627689; 26074081
185TPSVKKDSFFLDLSCdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20068231; 18988627; 22135298;
Sequence
(Fasta)		MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR KRNAFRIQVE 60
KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY SDDDSSMEDY PDPQSANHMN 120
SSLLSLYRKG NPDSVSNTPE MEQRETTSST PRISSKTGSI PLKTPAKDSE GGWFIDKTPS 180
VKKDSFFLDL SCEKSNPKKP ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG 240
EIEAVLQKKA KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG 300
VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF EQAVSNAPCI 360
IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA TARVLVIGAT NRPDSLDPAL 420
RRAGRFDREI CLGIPDEASR ERILQTLCRK LRLPQAFDFC HLAHLTPGFV GADLMALCRE 480
AAMCAVNRVL MKLQEQQKKN PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP 540
LSEEQMQGLC IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP 600
VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE LLNMYVGESE 660
RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR VVNQLLTEMD GLEARQQVFI 720
MAATNRPDII DPAILRPGRL DKTLFVGLPP PADRLAILKT ITKNGTKPPL DADVNLEAIA 780
GDLRCDCYTG ADLSALVREA SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS 840
KKDQIMYERL QESLSR 857
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
Interpro

IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR031996--NVL2_nucleolin-bd
IPR027417--P-loop_NTPase
PROSITE

PS00674--AAA
Pfam

PF00004--AAA
PF16725--Nucleolin_bd
Gene Ontology

GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005697--C:telomerase holoenzyme complex
GO:0005524--F:ATP binding
GO:0044822--F:poly(A) RNA binding
GO:1990275--F:preribosome binding
GO:0051973--P:positive regulation of telomerase activity
GO:0042254--P:ribosome biogenesis