dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000944
Uniprot Accession O15379; HDAC3_HUMAN; D3DQE1; O43268; Q9UEI5; Q9UEV0;
Genbank Protein ID NP_003874.2;
Genbank Nucleotide ID NM_003883.3;
Protein Name Histone deacetylase 3
Protein Synonyms/Alias
Gene Name HDAC3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
74IDFLQRVSPTNMQGFPhosphoSitePlus;curated22135298; 23917254
191TDRVMTVSFHKYGNYcurated22817900; 20068231
331PYSEYFEYFAPDFTLPhosphoSitePlus22135298
404ERGPEENYSRPEAPNdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.017081983; 16381945; 23193290; 18988627; 22135298; 19366988
405RGPEENYSRPEAPNEdbPTM 3.0;HPRD 9;SysPTM 2.017081983; 16381945; 23193290; 18988627; 19366988
414PEAPNEFYDGDHDNDPhosphoSitePlus;curated22135298; 20873877; 23663014; 24667141
424DHDNDKESDVEI---dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19690332; 16381945; 23193290; 17081983; 15805470; 19276368;
Sequence
(Fasta)		MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR 60
FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN 120
KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA 180
FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI 240
NQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV 300
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ 360
TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN 420
DKESDVEI 429
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
PROSITE
Pfam

PF00850--Hist_deacetyl
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000118--C:histone deacetylase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005876--C:spindle microtubule
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0030332--F:cyclin binding
GO:0019899--F:enzyme binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051059--F:NF-kappaB binding
GO:0033558--F:protein deacetylase activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0044255--P:cellular lipid metabolic process
GO:0071498--P:cellular response to fluid shear stress
GO:0016568--P:chromatin modification
GO:0006325--P:chromatin organization
GO:0032922--P:circadian regulation of gene expression
GO:0007623--P:circadian rhythm
GO:0043066--P:negative regulation of apoptotic process
GO:2000726--P:negative regulation of cardiac muscle cell differentiation
GO:0045786--P:negative regulation of cell cycle
GO:0046329--P:negative regulation of JNK cascade
GO:1903507--P:negative regulation of nucleic acid-templated transcription
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0007219--P:Notch signaling pathway
GO:0001934--P:positive regulation of protein phosphorylation
GO:0032008--P:positive regulation of TOR signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006476--P:protein deacetylation
GO:0007346--P:regulation of mitotic cell cycle
GO:0040014--P:regulation of multicellular organism growth
GO:0031647--P:regulation of protein stability
GO:0044281--P:small molecule metabolic process
GO:0051225--P:spindle assembly
GO:0006351--P:transcription, DNA-templated