dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000943
Uniprot Accession O15375; MOT6_HUMAN; B4E288;
Genbank Protein ID NP_001258694.1; NP_004686.1; XP_005257848.1;
Genbank Nucleotide ID NM_001271765.1; NM_004695.3; XM_005257791.2;
Protein Name Monocarboxylate transporter 6
Protein Synonyms/Alias
Gene Name SLC16A5
Gene Synonyms/Alias MCT5;MCT6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
195IIRPVATSVAPETKEcurated26074081
200ATSVAPETKECPPPPcurated26074081
451DGPGKQRSPEIMCQSPhosphoSitePlus;curated22135298; 25627689
Sequence
(Fasta)		MPQALERADG SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS ETSWFPSILT 60
AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS HNLSQLYFTA GFITGLGMCF 120
SFQSSITVLG FYFVRRRVLA NALASMGVSL GITLWPLLSR YLLENLGWRG TFLVFGGIFL 180
HCCICGAIIR PVATSVAPET KECPPPPPET PALGCLAACG RTIQRHLAFD ILRHNTGYCV 240
YILGVMWSVL GFPLPQVFLV PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF 300
ASHRKYLFSL ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF QVLMDIVPMD 360
QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM SSFFLISAAL FMGGSFYALQ 420
KKEQGKQAVA ADALERDLFL EAKDGPGKQR SPEIMCQSSR QPRPAGVNKH LWGCPASSRT 480
SHEWLLWPKA VLQAKQTALG WNSPT 506
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR004743--MCT
IPR030760--MCT6
IPR011701--MFS
IPR020846--MFS_dom
PROSITE

PS50850--MFS
Pfam

PF07690--MFS_1
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0015129--F:lactate transmembrane transporter activity
GO:0008028--F:monocarboxylic acid transmembrane transporter activity
GO:0015293--F:symporter activity
GO:0015718--P:monocarboxylic acid transport
GO:0035879--P:plasma membrane lactate transport