dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000942
Uniprot Accession O15374; MOT5_HUMAN; A8K3V5; B2R9C9; B4DJ67; B4DPX7; E7EPY8; G3V175; Q5T612; Q8WU09;
Genbank Protein ID NP_001188475.1; NP_001188476.1; NP_001188477.1; NP_001188478.1; NP_004687.1; XP_005271374.1;
Genbank Nucleotide ID NM_001201546.1; NM_001201547.1; NM_001201548.1; NM_001201549.1; NM_004696.2; XM_005271317.3;
Protein Name Monocarboxylate transporter 5
Protein Synonyms/Alias
Gene Name SLC16A4
Gene Synonyms/Alias MCT4;MCT5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
11REGKVQPYTKTLDGGPhosphoSitePlus22135298
12EGKVQPYTKTLDGGWPhosphoSitePlus22135298
147FKKRLALSTAIARSGPhosphoSitePlus22135298
148KKRLALSTAIARSGMPhosphoSitePlus22135298
158ARSGMGLTFLLAPFTPhosphoSitePlus22135298
165TFLLAPFTKFLIDLYPhosphoSitePlus22135298
341MDASYLVSVAGILETPhosphoSitePlus22135298
354ETVSQIISGWVADQNPhosphoSitePlus22135298
Sequence
(Fasta)		MLKREGKVQP YTKTLDGGWG WMIVIHFFLV NVFVMGMTKT FAIFFVVFQE EFEGTSEQIG 60
WIGSIMSSLR FCAGPLVAII CDILGEKTTS ILGAFVVTGG YLISSWATSI PFLCVTMGLL 120
PGLGSAFLYQ VAAVVTTKYF KKRLALSTAI ARSGMGLTFL LAPFTKFLID LYDWTGALIL 180
FGAIALNLVP SSMLLRPIHI KSENNSGIKD KGSSLSAHGP EAHATETHCH ETEESTIKDS 240
TTQKAGLPSK NLTVSQNQSE EFYNGPNRNR LLLKSDEESD KVISWSCKQL FDISLFRNPF 300
FYIFTWSFLL SQLAYFIPTF HLVARAKTLG IDIMDASYLV SVAGILETVS QIISGWVADQ 360
NWIKKYHYHK SYLILCGITN LLAPLATTFP LLMTYTICFA IFAGGYLALI LPVLVDLCRN 420
STVNRFLGLA SFFAGMAVLS GPPIAGWLYD YTQTYNGSFY FSGICYLLSS VSFFFVPLAE 480
RWKNSLT 488
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR011701--MFS
IPR020846--MFS_dom
PROSITE

PS50850--MFS
Pfam

PF07690--MFS_1
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0008028--F:monocarboxylic acid transmembrane transporter activity
GO:0015293--F:symporter activity
GO:0034220--P:ion transmembrane transport
GO:0015718--P:monocarboxylic acid transport