dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000941
Uniprot Accession O15372; EIF3H_HUMAN;
Genbank Protein ID NP_003747.1;
Genbank Nucleotide ID NM_003756.2;
Protein Name Eukaryotic translation initiation factor 3 subunit H
Protein Synonyms/Alias
Gene Name EIF3H
Gene Synonyms/Alias EIF3S3;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
3-----MASRKEGTGSPhosphoSitePlus;curated22135298; 23186163; 26074081
8MASRKEGTGSTATSSdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17924679; 16381945; 23193290; 18988627; 19060867; 22135298;
10SRKEGTGSTATSSSSdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17924679; 16381945; 23193290; 18988627; 19060867; 22135298;
11RKEGTGSTATSSSSTdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 19060867; 22135298
14GTGSTATSSSSTAGAcurated25627689
15TGSTATSSSSTAGAAcurated25627689; 23911959
16GSTATSSSSTAGAAGcurated25627689
17STATSSSSTAGAAGKPhosphoSitePlus;curated22135298; 25627689
18TATSSSSTAGAAGKGcurated25627689
31KGKGKGGSGDSAVKQdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068230; 16381945; 23193290; 18988627; 22135298; 22817900
163KTAQGSLSLKAYRLTPhosphoSitePlus22135298
183VCKEKDFSPEALKKAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 17322308; 18691976; 16381945; 23193290; 18544531;
236ELLSLASSNHLGKNLcurated23898821; 24961811
262QDIVKYNTYMRNTSKPhosphoSitePlus22135298
263DIVKYNTYMRNTSKQPhosphoSitePlus22135298
277QQQQKHQYQQRRQQEcurated26074081
290QENMQRQSRGEPPLPPhosphoSitePlus;curated22135298; 25627689
316QPPARMDSLLIAGQIPhosphoSitePlus22135298
Sequence
(Fasta)		MASRKEGTGS TATSSSSTAG AAGKGKGKGG SGDSAVKQVQ IDGLVVLKII KHYQEEGQGT 60
EVVQGVLLGL VVEDRLEITN CFPFPQHTED DADFDEVQYQ MEMMRSLRHV NIDHLHVGWY 120
QSTYYGSFVT RALLDSQFSY QHAIEESVVL IYDPIKTAQG SLSLKAYRLT PKLMEVCKEK 180
DFSPEALKKA NITFEYMFEE VPIVIKNSHL INVLMWELEK KSAVADKHEL LSLASSNHLG 240
KNLQLLMDRV DEMSQDIVKY NTYMRNTSKQ QQQKHQYQQR RQQENMQRQS RGEPPLPEED 300
LSKLFKPPQP PARMDSLLIA GQINTYCQNI KEFTAQNLGK LFMAQALQEY NN 353
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
Interpro

IPR027524--eIF3h
IPR000555--JAMM/MPN+_dom
PROSITE
Pfam

PF01398--JAB
Gene Ontology

GO:0005829--C:cytosol
GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0044822--F:poly(A) RNA binding
GO:0003743--F:translation initiation factor activity
GO:0044267--P:cellular protein metabolic process
GO:0001731--P:formation of translation preinitiation complex
GO:0010467--P:gene expression
GO:0006446--P:regulation of translational initiation
GO:0006412--P:translation
GO:0006413--P:translational initiation