dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000938
Uniprot Accession O15360; FANCA_HUMAN; A5D923; B4DRI7; H3BSR5; O75266; Q6PL10; Q92497; Q96H18; Q9UEA5; Q9UEL8; Q9UEL9; Q9UPK3; Q9Y6M2;
Genbank Protein ID NP_000126.2; NP_001018122.1; NP_001273096.1;
Genbank Nucleotide ID NM_000135.2; NM_001018112.1; NM_001286167.1;
Protein Name Fanconi anemia group A protein
Protein Synonyms/Alias
Gene Name FANCA
Gene Synonyms/Alias FAA;FACA;FANCH;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
303RCWFGVFSGHTLGSVPhosphoSitePlus22135298
309FSGHTLGSVISTDPLPhosphoSitePlus22135298
323LKRFFSHTLTQILTHPhosphoSitePlus22135298
329HTLTQILTHSPVLKAPhosphoSitePlus22135298
337HSPVLKASDAVQMQRPhosphoSitePlus22135298
351REWSFARTHPLLTSLPhosphoSitePlus22135298
357RTHPLLTSLYRRLFVPhosphoSitePlus22135298
421LMAQAFESCQLDSMVPhosphoSitePlus22135298
458WFKASFGSTRGYHGCPhosphoSitePlus22135298
488VPFESPRYLQVHILHPhosphoSitePlus22135298
849SYSLCKFSSQSRDTLdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 22135298
850YSLCKFSSQSRDTLCdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 22135298
858QSRDTLCSCLSPGLIdbPTM 3.0;HPRD 9;PhosphoSitePlus17924679; 16381945; 23193290; 18988627; 22135298
1149CLRSRDPSLMVDFILdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated11855836; 16381945; 23193290; 18988627; 22135298; 22817900
1208QEGRQFASDFLSPEAPhosphoSitePlus22135298
1301CLEKRKISWLALFQLPhosphoSitePlus22135298
1309WLALFQLTESDLRLGPhosphoSitePlus22135298
1449AAPDADLSQEPHLF-dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17525332; 18691976; 16381945; 23193290; 19109555; 18077418;
Sequence
(Fasta)		MSDSWVPNSA SGQDPGGRRR AWAELLAGRV KREKYNPERA QKLKESAVRL LRSHQDLNAL 60
LLEVEGPLCK KLSLSKVIDC DSSEAYANHS SSFIGSALQD QASRLGVPVG ILSAGMVASS 120
VGQICTAPAE TSHPVLLTVE QRKKLSSLLE FAQYLLAHSM FSRLSFCQEL WKIQSSLLLE 180
AVWHLHVQGI VSLQELLESH PDMHAVGSWL FRNLCCLCEQ MEASCQHADV ARAMLSDFVQ 240
MFVLRGFQKN SDLRRTVEPE KMPQVTVDVL QRMLIFALDA LAAGVQEESS THKIVRCWFG 300
VFSGHTLGSV ISTDPLKRFF SHTLTQILTH SPVLKASDAV QMQREWSFAR THPLLTSLYR 360
RLFVMLSAEE LVGHLQEVLE TQEVHWQRVL SFVSALVVCF PEAQQLLEDW VARLMAQAFE 420
SCQLDSMVTA FLVVRQAALE GPSAFLSYAD WFKASFGSTR GYHGCSKKAL VFLFTFLSEL 480
VPFESPRYLQ VHILHPPLVP GKYRSLLTDY ISLAKTRLAD LKVSIENMGL YEDLSSAGDI 540
TEPHSQALQD VEKAIMVFEH TGNIPVTVME ASIFRRPYYV SHFLPALLTP RVLPKVPDSR 600
VAFIESLKRA DKIPPSLYST YCQACSAAEE KPEDAALGVR AEPNSAEEPL GQLTAALGEL 660
RASMTDPSQR DVISAQVAVI SERLRAVLGH NEDDSSVEIS KIQLSINTPR LEPREHMAVD 720
LLLTSFCQNL MAASSVAPPE RQGPWAALFV RTMCGRVLPA VLTRLCQLLR HQGPSLSAPH 780
VLGLAALAVH LGESRSALPE VDVGPPAPGA GLPVPALFDS LLTCRTRDSL FFCLKFCTAA 840
ISYSLCKFSS QSRDTLCSCL SPGLIKKFQF LMFRLFSEAR QPLSEEDVAS LSWRPLHLPS 900
ADWQRAALSL WTHRTFREVL KEEDVHLTYQ DWLHLELEIQ PEADALSDTE RQDFHQWAIH 960
EHFLPESSAS GGCDGDLQAA CTILVNALMD FHQSSRSYDH SENSDLVFGG RTGNEDIISR 1020
LQEMVADLEL QQDLIVPLGH TPSQEHFLFE IFRRRLQALT SGWSVAASLQ RQRELLMYKR 1080
ILLRLPSSVL CGSSFQAEQP ITARCEQFFH LVNSEMRNFC SHGGALTQDI TAHFFRGLLN 1140
ACLRSRDPSL MVDFILAKCQ TKCPLILTSA LVWWPSLEPV LLCRWRRHCQ SPLPRELQKL 1200
QEGRQFASDF LSPEAASPAP NPDWLSAAAL HFAIQQVREE NIRKQLKKLD CEREELLVFL 1260
FFFSLMGLLS SHLTSNSTTD LPKAFHVCAA ILECLEKRKI SWLALFQLTE SDLRLGRLLL 1320
RVAPDQHTRL LPFAFYSLLS YFHEDAAIRE EAFLHVAVDM YLKLVQLFVA GDTSTVSPPA 1380
GRSLELKGQG NPVELITKAR LFLLQLIPRC PKKSFSHVAE LLADRGDCDP EVSAALQSRQ 1440
QAAPDADLSQ EPHLF 1456
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0923--Fanconi anemia
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR003516--FANCA
IPR031729--Fanconi_A_N
PROSITE
Pfam

PF03511--Fanconi_A
PF15865--Fanconi_A_N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0006281--P:DNA repair
GO:0008585--P:female gonad development
GO:0036297--P:interstrand cross-link repair
GO:0008584--P:male gonad development
GO:0007140--P:male meiosis
GO:0006461--P:protein complex assembly
GO:0042127--P:regulation of cell proliferation