| Tag |
Content |
| dbPAF ID |
dbPAF-0000935 |
| Uniprot Accession |
O15354; GPR37_HUMAN; A4D0Y6; O00348; O14768; Q8TD39;
|
| Genbank Protein ID |
NP_005293.1;
|
| Genbank Nucleotide ID |
NM_005302.3;
|
| Protein Name |
Prosaposin receptor GPR37 |
| Protein Synonyms/Alias |
Endothelin B receptor-like protein 1;ETBR-LP-1;G-protein coupled receptor 37;Parkin-associated endothelin receptor-like receptor;PAELR; |
| Gene Name |
GPR37 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.Functional Description
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ RRGRDAWGPG 60
NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR GAEASAAGPP GPPTRPPGPW 120
RWKGARGQEP SETLGRGNPT ALQLFLQISE EEEKGPRGAG ISGRSQEQSV KTVPGASDLF 180
YWPRRAGKLQ GSHHKPLSKT ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS 240
TNRRVRLKNP FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL 300
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF 360
RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGRAPAERCI 420
IKISPDLPDT IYVLALTYDS ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKACTRGN 480
KRQIQLESQM NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF 540
KSCVTPVLLF CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR 600
REMSTFASVG THC
614Fasta Sequence
>O15354|GPR37|Homo sapiens(Human)
MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0675--Receptor
KW-1185--Reference proteome
KW-0732--Signal
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
|
| Interpro |
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR003909--GPR37_orph
|
| PROSITE |
PS50262--G_PROTEIN_RECEP_F1_2
|
| Pfam |
PF00001--7tm_1
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0043235--C:receptor complex
GO:0000151--C:ubiquitin ligase complex
GO:0008528--F:G-protein coupled peptide receptor activity
GO:0004930--F:G-protein coupled receptor activity
GO:0031072--F:heat shock protein binding
GO:0030544--F:Hsp70 protein binding
GO:0042277--F:peptide binding
GO:0036505--F:prosaposin receptor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0007193--P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0042416--P:dopamine biosynthetic process
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0031987--P:locomotion involved in locomotory behavior
GO:1903206--P:negative regulation of hydrogen peroxide-induced cell death
GO:0045964--P:positive regulation of dopamine metabolic process
GO:0043410--P:positive regulation of MAPK cascade
|
