dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000933
Uniprot Accession O15350; P73_HUMAN; B7Z7J4; B7Z8Z1; B7Z9C1; C9J521; O15351; Q17RN8; Q5TBV5; Q5TBV6; Q8NHW9; Q8TDY5; Q8TDY6; Q9NTK8;
Genbank Protein ID NP_001119712.1; NP_001119713.1; NP_001119714.1; NP_001191113.1; NP_001191114.1; NP_001191115.1; NP_001191116.1; NP_001191117.1; NP_001191118.1; NP_001191119.1; NP_001191120.1; NP_001191121.1; NP_005418.1; XP_011540366.1;
Genbank Nucleotide ID NM_001126240.2; NM_001126241.2; NM_001126242.2; NM_001204184.1; NM_001204185.1; NM_001204186.1; NM_001204187.1; NM_001204188.1; NM_001204189.1; NM_001204190.1; NM_001204191.1; NM_001204192.1; NM_005427.3; XM_011542064.1;
Protein Name Tumor protein p73
Protein Synonyms/Alias p53-like transcription factor;p53-related protein;
Gene Name TP73
Gene Synonyms/Alias P73;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
Phosphorylation Sites
dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
27SSLEPDSTYFDLPQSdbPTM 3.0;PhosphoSitePlus;curated18174154; 18418051; 16381945; 23193290; 22135298; 22817900
28SLEPDSTYFDLPQSSdbPTM 3.0;PhosphoSitePlus;curated17535448; 16381945; 23193290; 22135298; 22817900
47EVVGGTDSSMDVFHLdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated14585975; 16381945; 23193290; 22135298; 22817900
86AASASPYTPEHAASVdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated12676926; 16381945; 23193290; 15985436; 22002055; 18988627;
99SVPTHSPYAQPSSTFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated10391251; 16381945; 23193290; 10391250; 17535448; 20057499;
167PIQIKVSTPPPPGTAPhosphoSitePlus22135298
173STPPPPGTAIRAMPVPhosphoSitePlus22135298
181AIRAMPVYKKAEHVTcurated20873877
235DPVTGRQSVVVPYEPdbPTM 3.0;PhosphoSitePlus22340593; 16381945; 23193290; 22135298
289GQVLGRRSFEGRICAPhosphoSitePlus22135298
333SKRAFKQSPPAVPALcurated23898821
388VPQPLVDSYRQQQQLdbPTM 3.0;PhosphoSitePlus;curated19158275; 16381945; 23193290; 22135298; 22817900
426GGMNKLPSVNQLVGQPhosphoSitePlus22135298
471GEMSSSHSAQSMVSGdbPTM 3.0;PhosphoSitePlus21482671; 16381945; 23193290; 22135298
568LRSSNAATISIGGSGPhosphoSitePlus22135298
Sequence
(Fasta)
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS 60
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD 120
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV 180
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY 240
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR 300
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR 360
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG 420
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH 480
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT 540
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG 600
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH 637
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0862--Zinc

Interpro

IPR008967--p53-like_TF_DNA-bd
IPR012346--p53/RUNT-type_TF_DNA-bd
IPR011615--p53_DNA-bd
IPR010991--p53_tetrameristn
IPR002117--p53_tumour_suppressor
IPR001660--SAM
IPR013761--SAM/pointed
IPR032646--Tp73

PROSITE

PS00348--P53

Pfam

PF00870--P53
PF07710--P53_tetramer
PF07647--SAM_2

Gene Ontology

GO:0030054--C:cell junction
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003684--F:damaged DNA binding
GO:0003690--F:double-stranded DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0002039--F:p53 binding
GO:0019901--F:protein kinase binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000187--P:activation of MAPK activity
GO:0007050--P:cell cycle arrest
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0033326--P:cerebrospinal fluid secretion
GO:0048546--P:digestive tract morphogenesis
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0021766--P:hippocampus development
GO:0006954--P:inflammatory response
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0001822--P:kidney development
GO:0006298--P:mismatch repair
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0060044--P:negative regulation of cardiac muscle cell proliferation
GO:0008285--P:negative regulation of cell proliferation
GO:0043508--P:negative regulation of JUN kinase activity
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0045665--P:negative regulation of neuron differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048666--P:neuron development
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045793--P:positive regulation of cell size
GO:1902167--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0009791--P:post-embryonic development
GO:0051262--P:protein tetramerization
GO:0010468--P:regulation of gene expression
GO:0007346--P:regulation of mitotic cell cycle
GO:0042493--P:response to drug
GO:0010332--P:response to gamma radiation
GO:0010243--P:response to organonitrogen compound
GO:0010165--P:response to X-ray
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016032--P:viral process