dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000932
Uniprot Accession O15347; HMGB3_HUMAN; O95556; Q6NS40;
Genbank Protein ID NP_001288157.1; NP_001288158.1; NP_001288160.1; NP_005333.2;
Genbank Nucleotide ID NM_001301228.1; NM_001301229.1; NM_001301231.1; NM_005342.3;
Protein Name High mobility group protein B3
Protein Synonyms/Alias High mobility group protein 2a;HMG-2a;High mobility group protein 4;HMG-4;
Gene Name HMGB3
Gene Synonyms/Alias HMG2A;HMG4;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
14KKPKGKMSAYAFFVQPhosphoSitePlus22135298
42PVNFAEFSKKCSERWcurated20068231; 22817900
58TMSGKEKSKFDEMAKPHOSIDA21081558
71AKADKVRYDREMKDYPhosphoSitePlus22135298
78YDREMKDYGPAKGGKPhosphoSitePlus22135298
98NAPKRPPSGFFLFCSPhosphoSitePlus;curated22135298; 23898821; 21857030
105SGFFLFCSEFRPKIKPhosphoSitePlus;curated22135298; 21857030
113EFRPKIKSTNPGISIPHOSIDA21081558
114FRPKIKSTNPGISIGPHOSIDA;PhosphoSitePlus21081558; 22135298
119KSTNPGISIGDVAKKPhosphoSitePlus22135298
Sequence
(Fasta)		MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSGKEKSKF 60
DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI 120
GDVAKKLGEM WNNLNDSEKQ PYITKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV 180
EEEDEEEEEE EEEEEEEEDE 201
Keyword

KW-0002--3D-structure
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0238--DNA-binding
KW-0391--Immunity
KW-0399--Innate immunity
KW-1013--Microphthalmia
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR009071--HMG_box_dom
IPR017967--HMG_boxA_CS
IPR031077--HMGB3
PROSITE

PS00353--HMG_BOX_1
PS50118--HMG_BOX_2
Pfam

PF00505--HMG_box
PF09011--HMG_box_2
Gene Ontology

GO:0005694--C:chromosome
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0008301--F:DNA binding, bending
GO:0003690--F:double-stranded DNA binding
GO:0000400--F:four-way junction DNA binding
GO:0044822--F:poly(A) RNA binding
GO:0006338--P:chromatin remodeling
GO:0032392--P:DNA geometric change
GO:0006310--P:DNA recombination
GO:0007275--P:multicellular organismal development
GO:0045578--P:negative regulation of B cell differentiation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated