dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000930
Uniprot Accession O15327; INP4B_HUMAN; Q2TAI2; Q5XLE7; Q6IN59; Q6PJB4;
Genbank Protein ID NP_001095139.1; NP_003857.2; XP_006714465.1;
Genbank Nucleotide ID NM_001101669.1; NM_003866.2; XM_006714402.1;
Protein Name Type II inositol 3,4-bisphosphate 4-phosphatase
Protein Synonyms/Alias Inositol polyphosphate 4-phosphatase type II;
Gene Name INPP4B
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
61VRDRKLNTLVQISVIPhosphoSitePlus22135298
66LNTLVQISVIHPVEQPhosphoSitePlus22135298
74VIHPVEQSLTRYSSTPhosphoSitePlus22135298
76HPVEQSLTRYSSTEIPhosphoSitePlus22135298
94TRDPLFLTGVTFPSEcurated25627689; 26074081
97PLFLTGVTFPSEYPIcurated25627689
100LTGVTFPSEYPIYEEcurated25627689
108EYPIYEETKIKLTVYcurated26074081
115TKIKLTVYDVKDKSHPhosphoSitePlus22135298
121VYDVKDKSHDTVRTSPhosphoSitePlus22135298
147VGRSFLGYASFKVGEPhosphoSitePlus22135298
198DGEADHITTDVQGQKdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
270HIPKELISLHIKEDLPhosphoSitePlus22135298
290IKELGELSPHWDNLRcurated23898821
468FKDQLVRSALLALYTPhosphoSitePlus22135298
487GILKKPPSPKSSTEEcurated22798277
496KSSTEESSPQDQPPVcurated25849741
792MEKMPPDYISHFQEQdbPTM 3.0;HPRD 9;SysPTM 2.017322306; 16381945; 23193290; 18988627; 19366988
794KMPPDYISHFQEQNDdbPTM 3.0;HPRD 917322306; 16381945; 23193290; 18988627
898KNIKCRKYAFNMLQLdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MEIKEEGASE EGQHFLPTAQ ANDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN 60
TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK 120
SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLVLSLRTS DGGKVVGTIE 180
VSVVKMGEIE DGEADHITTD VQGQKCALVC ECTAPESVSG KDNLPFLNSV LKNPVCKLYR 240
FPTSDNKWMR IREQMSESIL SFHIPKELIS LHIKEDLCRN QEIKELGELS PHWDNLRKNV 300
LTHCDQMVNM YQDILTELSK ETGSSFKSSS SKGEKTLEFV PINLHLQRMQ VHSPHLKDAL 360
YDVITVGAPA AHFQGFKNGG LRKLLHRFET ERRNTGYQFI YYSPENTAKA KEVLSNINQL 420
QPLIATHADL LLNSASQHSP DSLKNSLKML SEKTELFVHA FKDQLVRSAL LALYTARPGG 480
ILKKPPSPKS STEESSPQDQ PPVMRGQDSI PHHSDYDEEE WDRVWANVGK SLNCIIAMVD 540
KLIERDGGSE GSGGNNDGEK EPSLTDAIPS HPREDWYEQL YPLILTLKDC MGEVVNRAKQ 600
SLTFVLLQEL AYSLPQCLML TLRRDIVFSQ ALAGLVCGFI IKLQTSLYDP GFLQQLHTVG 660
LIVQYEGLLS TYSDEIGMLE DMAVGISDLK KVAFKIIEAK SNDVLPVITG RREHYVVEVK 720
LPARMFESLP LQIKEGQLLH VYPVLFNVGI NEQQTLAERF GDVSLQESIN QENFELLQEY 780
YKIFMEKMPP DYISHFQEQN DLKALLENLL QNIQSKKRKN VEIMWLAATI CRKLNGIRFT 840
CCKSAKDRTS MSVTLEQCSI LRDEHQLHKD FFIRALDCMR REGCRIENVL KNIKCRKYAF 900
NMLQLMAFPK YYRPPEGTYG KADT 925
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR000008--C2_dom
PROSITE
Pfam
Gene Ontology

GO:0005829--C:cytosol
GO:0008289--F:lipid binding
GO:0034594--F:phosphatidylinositol trisphosphate phosphatase activity
GO:0016316--F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597--F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0006874--P:cellular calcium ion homeostasis
GO:0043647--P:inositol phosphate metabolic process
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0036092--P:phosphatidylinositol-3-phosphate biosynthetic process
GO:0006644--P:phospholipid metabolic process
GO:0046850--P:regulation of bone remodeling
GO:0046822--P:regulation of nucleocytoplasmic transport
GO:0051896--P:regulation of protein kinase B signaling
GO:0007165--P:signal transduction
GO:0044281--P:small molecule metabolic process