| Tag |
Content |
| dbPAF ID |
dbPAF-0000928 |
| Uniprot Accession |
O15318; RPC7_HUMAN; A8MTH0;
|
| Genbank Protein ID |
NP_006458.2; XP_005248461.1; XP_006714582.1; XP_006714583.1; XP_011541402.1; XP_011541403.1; XP_011541404.1;
|
| Genbank Nucleotide ID |
NM_006467.2; XM_005248404.2; XM_006714519.2; XM_006714520.2; XM_011543100.1; XM_011543101.1; XM_011543102.1;
|
| Protein Name |
DNA-directed RNA polymerase III subunit RPC7 |
| Protein Synonyms/Alias |
|
| Gene Name |
POLR3G |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.Functional Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MAGNKGRGRA AYTFNIEAVG FSKGEKLPDV VLKPPPLFPD TDYKPVPLKT GEGEEYMLAL 60
KQELRETMKR MPYFIETPEE RQDIERYSKR YMKVYKEEWI PDWRRLPREM MPRNKCKKAG 120
PKPKKAKDAG KGTPLTNTED VLKKMEELEK RGDGEKSDEE NEEKEGSKEK SKEGDDDDDD 180
DAAEQEEYDE EEQEEENDYI NSYFEDGDDF GADSDDNMDE ATY
224Fasta Sequence
>O15318|POLR3G|Homo sapiens(Human)
MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY
|
| Keyword |
KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0240--DNA-directed RNA polymerase
KW-0391--Immunity
KW-0399--Innate immunity
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
|
| Interpro |
IPR024661--RNA_pol_III_Rpc31
|
| PROSITE |
|
| Pfam |
PF11705--RNA_pol_3_Rpc31
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005666--C:DNA-directed RNA polymerase III complex
GO:0005654--C:nucleoplasm
GO:0003899--F:DNA-directed RNA polymerase activity
GO:0008283--P:cell proliferation
GO:0051607--P:defense response to virus
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0045089--P:positive regulation of innate immune response
GO:0032728--P:positive regulation of interferon-beta production
GO:0032481--P:positive regulation of type I interferon production
GO:0006359--P:regulation of transcription from RNA polymerase III promoter
GO:0006386--P:termination of RNA polymerase III transcription
GO:0006385--P:transcription elongation from RNA polymerase III promoter
GO:0006383--P:transcription from RNA polymerase III promoter
GO:0006384--P:transcription initiation from RNA polymerase III promoter
|
