| Tag |
Content |
| dbPAF ID |
dbPAF-0000927 |
| Uniprot Accession |
O15315; RA51B_HUMAN; O60914; O75210; Q3Y4F8; Q6FHX8; Q86SY3; Q86SY4; Q86TR0; Q86U92; Q86U93; Q86U94; Q8N6H4; Q9UPL5;
|
| Genbank Protein ID |
NP_002868.1; NP_598193.2; NP_598194.1;
|
| Genbank Nucleotide ID |
NM_002877.5; NM_133509.3; NM_133510.3;
|
| Protein Name |
DNA repair protein RAD51 homolog 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
RAD51B |
| Gene Synonyms/Alias |
RAD51L1;REC2; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.Functional Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 66 | ACAPKMQTAYGIKAQ | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MGSKKLKRVG LSQELCDRLS RHQILTCQDF LCLSPLELMK VTGLSYRGVH ELLCMVSRAC 60
APKMQTAYGI KAQRSADFSP AFLSTTLSAL DEALHGGVAC GSLTEITGPP GCGKTQFCIM 120
MSILATLPTN MGGLEGAVVY IDTESAFSAE RLVEIAESRF PRYFNTEEKL LLTSSKVHLY 180
RELTCDEVLQ RIESLEEEII SKGIKLVILD SVASVVRKEF DAQLQGNLKE RNKFLAREAS 240
SLKYLAEEFS IPVILTNQIT THLSGALASQ ADLVSPADDL SLSEGTSGSS CVIAALGNTW 300
SHSVNTRLIL QYLDSERRQI LIAKSPLAPF TSFVYTIKEE GLVLQETTFC SVTQAELNWA 360
PEILPPQPPE QLGLQMCHHT QLIF
385Fasta Sequence
>O15315|RAD51B|Homo sapiens(Human)
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
|
| Interpro |
IPR003593--AAA+_ATPase
IPR013632--DNA_recomb/repair_Rad51_C
IPR016467--DNA_recomb/repair_RecA-like
IPR027417--P-loop_NTPase
IPR030548--RAD51B
IPR020588--RecA_ATP-bd
|
| PROSITE |
PS50162--RECA_2
|
| Pfam |
PF08423--Rad51
|
| Gene Ontology |
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0033063--C:Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0005657--C:replication fork
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0008094--F:DNA-dependent ATPase activity
GO:0003690--F:double-stranded DNA binding
GO:0000150--F:recombinase activity
GO:0003697--F:single-stranded DNA binding
GO:0001832--P:blastocyst growth
GO:0007596--P:blood coagulation
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0006302--P:double-strand break repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045003--P:double-strand break repair via synthesis-dependent strand annealing
GO:0000707--P:meiotic DNA recombinase assembly
GO:0006312--P:mitotic recombination
GO:0008284--P:positive regulation of cell proliferation
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0007131--P:reciprocal meiotic recombination
GO:0010212--P:response to ionizing radiation
GO:0061053--P:somite development
GO:0042148--P:strand invasion
|
