dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000926
Uniprot Accession O15305; PMM2_HUMAN; A8K672; B7Z6R0; D3DUF3;
Genbank Protein ID NP_000294.1;
Genbank Nucleotide ID NM_000303.2;
Protein Name Phosphomannomutase 2
Protein Synonyms/Alias
Gene Name PMM2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
18FDVDGTLTAPRQKITPHOSIDA21081558
47KIGVVGGSDFEKVQEPhosphoSitePlus22135298
76PENGLVAYKDGKLLCPhosphoSitePlus22135298
130RNGMLNVSPIGRSCSPhosphoSitePlus22135298
145QEERIEFYELDKKENPhosphoSitePlus22135298
229TDPRTMGYSVTAPEDPHOSIDA21081558
230DPRTMGYSVTAPEDTPHOSIDA21081558
232RTMGYSVTAPEDTRRPHOSIDA21081558
237SVTAPEDTRRICELLPHOSIDA21081558
Sequence
(Fasta)		MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV 60
VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI 120
EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF 180
DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI 240
CELLFS 247
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0900--Congenital disorder of glycosylation
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0413--Isomerase
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR023214--HAD-like_dom
IPR006379--HAD-SF_hydro_IIB
IPR005002--PMM
PROSITE
Pfam

PF03332--PMM
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043025--C:neuronal cell body
GO:0004615--F:phosphomannomutase activity
GO:0044267--P:cellular protein metabolic process
GO:0006488--P:dolichol-linked oligosaccharide biosynthetic process
GO:0009298--P:GDP-mannose biosynthetic process
GO:0043687--P:post-translational protein modification
GO:0006486--P:protein glycosylation
GO:0018279--P:protein N-linked glycosylation via asparagine